RASSF1 and XPA

Number of citations of the paper that reports this interaction (PMID 10888881)
175

Data Source:
HPRD (two hybrid)

		RASSF1	XPA
Gene Name		Ras association (RalGDS/AF-6) domain family member 1	xeroderma pigmentosum, complementation group A
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Plasma Membrane Microtubule Cytoskeleton	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Protein N-terminus Binding	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Negative Regulation Of Cell Cycle Arrest	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth
Pathways			Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		33 interactors: ATP2B4 AURKA AURKB C7orf25 C8orf33 CDC20 CNKSR1 DAXX DDB1 E4F1 EXOSC8 HRAS IGFBP5 KCNE3 KDM1A MAP1B MAP1S MAPK8 MDM2 MOAP1 MST1 NUDT10 RASSF5 SAV1 STK3 STK4 SUV39H1 SUV39H2 TNFRSF10A TNFRSF1A TUBB TUBG1 XPA	20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2
Entrez ID		11186	7507
HPRD ID		05470	02045
Ensembl ID		ENSG00000068028	ENSG00000136936
Uniprot IDs		Q9NS23	P23025
PDB IDs		2KZU	1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Protein Binding Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Death Hippo Signaling Response To Abiotic Stimulus Mitotic Cell Cycle Process Positive Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Organ Growth Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Primitive Hemopoiesis Mitotic Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Transferase Activity Cell Cycle Response To UV Negative Regulation Of Protein Binding Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Organelle Organization Endocardium Development Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Hepatocyte Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Cycle Process Response To Light Stimulus Negative Regulation Of Developmental Growth Positive Regulation Of Cellular Metabolic Process	DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination
Tagcloud ?		bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley
Tagcloud (Difference) ?		bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley
Tagcloud (Intersection) ?