RASSF1 and KDELR2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RASSF1	KDELR2
Description		Ras association domain family member 1	KDEL endoplasmic reticulum protein retention receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Microtubule Cytoskeleton	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Zinc Ion Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding	KDEL Sequence Binding ER Retention Sequence Binding
	Biological Process	DNA Damage Response Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition	Protein Retention In ER Lumen Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Maintenance Of Protein Localization In Endoplasmic Reticulum
Pathways			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases		Nasopharyngeal cancer Non-small cell lung cancer Bladder cancer
GWAS		Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		68 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SMARCA4 STK11 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA	22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2
Entrez ID		11186	11014
HPRD ID		05470	06598
Ensembl ID		ENSG00000068028	ENSG00000136240
Uniprot IDs		Q9NS23	P33947
PDB IDs		2KZU
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Intracellular Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Protein Serine Kinase Activity Response To UV Regulation Of Signal Transduction By P53 Class Mediator Signal Transduction Regulation Of Mitotic Cell Cycle Response To Radiation Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Cellular Response To UV Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Programmed Cell Death Nucleotide Binding Cell Death Cellular Response To Light Stimulus Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Response To Light Stimulus Apoptotic Process Apoptotic Signaling Pathway Cell Cycle Phase Transition Cellular Response To Stress Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity ATP Binding Negative Regulation Of Signal Transduction Transferase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Phase Transition	Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Signal Transduction Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Regulation Of Signal Transduction ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Receptor Complex Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Protein Phosphorylation Regulation Of Catalytic Activity Nucleotide Binding Regulation Of Epithelial Cell Proliferation Phosphorylation Protein Autophosphorylation Positive Regulation Of Cellular Component Organization Peptidyl-tyrosine Phosphorylation Positive Regulation Of Fibroblast Proliferation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Phase Transition Positive Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Cell Cycle Phase Transition Positive Regulation Of Catalytic Activity Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Intracellular Signal Transduction Protein Serine Kinase Activity Cyclin D2-CDK4 Complex Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation
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