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RASSF1 and ARAF
Number of citations of the paper that reports this interaction (PubMedID
28205554
)
55
Data Source:
BioGRID
(fluorescent resonance energy transfer)
RASSF1
ARAF
Description
Ras association domain family member 1
A-Raf proto-oncogene, serine/threonine kinase
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Cytoplasm
Centrosome
Spindle
Cytoskeleton
Microtubule
Microtubule Cytoskeleton
Cytoplasm
Mitochondrion
Cytosol
Molecular Function
Protein Binding
Zinc Ion Binding
Small GTPase Binding
Identical Protein Binding
Metal Ion Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
DNA Damage Response
Signal Transduction
Ras Protein Signal Transduction
Positive Regulation Of Protein Ubiquitination
Protein Stabilization
Regulation Of Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
MAPK Cascade
Signal Transduction
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Protein Modification Process
Negative Regulation Of Apoptotic Process
Pathways
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
Drugs
ATP
Diseases
Nasopharyngeal cancer
Non-small cell lung cancer
Bladder cancer
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Basophil percentage of white cells (
32888494
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
High light scatter reticulocyte count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (
28991256
30285260
)
Sleep duration (short sleep) (
30846698
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
68 interacting genes:
AKT1
ARAF
ATM
ATP2B4
ATR
ATRX
AURKA
AURKB
BRAF
C7orf25
C8orf33
CCND2
CCNE1
CDC20
CDK4
CDK6
CDKN2A
CDKN2B
CLNK
CNKSR1
DAXX
DDB1
E4F1
EPHA2
ERBB2
EXOSC8
FGFR4
FZR1
GLIS2
GRM1
HRAS
IGFBP5
KAT2A
KCNE3
KDELR2
KDM1A
LATS2
MAP1B
MAP1S
MAP2K3
MAP2K6
MAPK8
MDM2
MET
MOAP1
MST1
MYC
NF2
NUDT10
PRKDC
RAF1
RASSF5
RELA
RHOA
RHOU
SMARCA4
STK11
STK4
SUV39H1
SUV39H2
TEAD2
TERT
TNFRSF10A
TNFRSF1A
TSC1
TUBB
TUBG1
XPA
57 interacting genes:
AGTRAP
AKT1
ASS1
BAD
BECN1
CCND2
CDK4
CDK6
CDKN2B
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
EPHA2
FGFR4
GLIS2
GNA12
HRAS
IRAK2
IRF7
KLHL12
LATS2
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MLH1
MYC
MYO18A
NELFCD
NF2
NRAS
NUDT14
PBK
PDGFRB
PIK3CA
PIK3R1
PKM
PRPF6
RABGGTB
RASSF1
RGS12
RRAS
RRAS2
SFN
STK11
TEKT4P2
TESK1
TIMM44
TIRAP
TP53
TSC1
WNK1
YWHAG
Entrez ID
11186
369
HPRD ID
05470
02405
Ensembl ID
ENSG00000068028
ENSG00000078061
Uniprot IDs
Q9NS23
A0A024R178
P10398
Q96II5
PDB IDs
2KZU
1WXM
2MSE
9AXM
Enriched GO Terms of Interacting Partners
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Regulation Of Cell Cycle
Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Cycle Phase Transition
Protein Serine Kinase Activity
Response To UV
Regulation Of Signal Transduction By P53 Class Mediator
Signal Transduction
Regulation Of Mitotic Cell Cycle
Response To Radiation
Cellular Response To Radiation
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Modification Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Cellular Response To UV
Regulation Of Macromolecule Metabolic Process
Regulation Of Cellular Component Organization
Regulation Of Apoptotic Process
Programmed Cell Death
Nucleotide Binding
Cell Death
Cellular Response To Light Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Protein Modification Process
Response To Light Stimulus
Apoptotic Process
Apoptotic Signaling Pathway
Cell Cycle Phase Transition
Cellular Response To Stress
Positive Regulation Of Cellular Component Organization
Regulation Of Catalytic Activity
ATP Binding
Negative Regulation Of Signal Transduction
Transferase Activity
Regulation Of Protein Phosphorylation
Mitotic Cell Cycle Phase Transition
Intracellular Signal Transduction
Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
ATP Binding
Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Kinase Activity
Protein Tyrosine Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Protein Serine Kinase Activity
Regulation Of Cell Population Proliferation
Positive Regulation Of Cellular Component Organization
MAP Kinase Kinase Activity
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
MAPK Cascade
Cell Surface Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Metabolic Process
Cellular Response To Stress
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Motility
Regulation Of Protein Localization
Regulation Of Catalytic Activity
Regulation Of Cell Cycle
Regulation Of Cell Adhesion
Regulation Of Epithelial Cell Proliferation
Regulation Of Locomotion
Regulation Of Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Protein Localization To Membrane
Apoptotic Signaling Pathway
Cellular Response To Radiation
Regulation Of Cellular Localization
Negative Regulation Of Macroautophagy
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Protein Phosphorylation
Positive Regulation Of Protein Localization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Phosphate-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
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Tagcloud (Intersection)
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