RASSF1 and MST1

Number of citations of the paper that reports this interaction (PMID 14729613)
15

Data Source:
BioGRID (two hybrid)

		RASSF1	MST1
Gene Name		Ras association (RalGDS/AF-6) domain family member 1	macrophage stimulating 1 (hepatocyte growth factor-like)
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Plasma Membrane Microtubule Cytoskeleton	Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Protein N-terminus Binding	Molecular_function Serine-type Endopeptidase Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Negative Regulation Of Cell Cycle Arrest	Proteolysis Spermatogenesis Embryo Implantation Biological_process Sperm Motility
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 17554261 17554300 21102463) Inflammatory bowel disease ( 23128233) Primary sclerosing cholangitis ( 21151127) Ulcerative colitis ( 19915572 20228799 21297633)
Protein-Protein Interactions		33 interactors: ATP2B4 AURKA AURKB C7orf25 C8orf33 CDC20 CNKSR1 DAXX DDB1 E4F1 EXOSC8 HRAS IGFBP5 KCNE3 KDM1A MAP1B MAP1S MAPK8 MDM2 MOAP1 MST1 NUDT10 RASSF5 SAV1 STK3 STK4 SUV39H1 SUV39H2 TNFRSF10A TNFRSF1A TUBB TUBG1 XPA	8 interactors: DAXX FOXO1 HIST2H2BE KLKB1 MOB1A MST1R RASSF1 SERPINA3
Entrez ID		11186	4485
HPRD ID		05470	00798
Ensembl ID		ENSG00000068028	ENSG00000173531
Uniprot IDs		Q9NS23	G3XAK1 P26927 Q53GN8
PDB IDs		2KZU	2ASU
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Protein Binding Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Death Hippo Signaling Response To Abiotic Stimulus Mitotic Cell Cycle Process Positive Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Organ Growth Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Primitive Hemopoiesis Mitotic Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Transferase Activity Cell Cycle Response To UV Negative Regulation Of Protein Binding Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Organelle Organization Endocardium Development Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Hepatocyte Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Cycle Process Response To Light Stimulus Negative Regulation Of Developmental Growth Positive Regulation Of Cellular Metabolic Process	Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stimulus Acute Inflammatory Response Factor XII Activation Nucleosome Assembly Chromatin Assembly Regulation Of MAPK Cascade Macrophage Colony-stimulating Factor Signaling Pathway Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Fibrinolysis Protein-DNA Complex Assembly DNA Packaging Regulation Of Stress-activated MAPK Cascade Innate Immune Response Regulation Of Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Cellular Response To Cold Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Macrophage Colony-stimulating Factor Stimulus Multicellular Organismal Homeostasis Positive Regulation Of Protein Modification Process Plasminogen Activation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Plasma Kallikrein-kinin Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Conformation Change Regulation Of Energy Homeostasis Regulation Of MAP Kinase Activity Cellular Response To Nitric Oxide Regulation Of Fibrinolysis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Response To Nitric Oxide Innate Immune Response In Mucosa Positive Regulation Of Gluconeogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Processing Epithelial Structure Maintenance Immune Response Regulation Of Phosphorylation Regulation Of Protein Processing Cellular Response To Reactive Nitrogen Species
Tagcloud ?		bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Difference) ?		bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Intersection) ?