IL2RG and CAPNS1

Number of citations of the paper that reports this interaction (PMID 9326644)
15

Data Source:
HPRD (two hybrid)

		IL2RG	CAPNS1
Gene Name		interleukin 2 receptor, gamma	calpain, small subunit 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	18 interactors: AGTRAP ARHGEF6 ARR3 ATP5J2 CAPN1 CAPN2 CAST CDK4 DRG1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5
Entrez ID		3561	826
HPRD ID		02391	00240
Ensembl ID		ENSG00000147168	ENSG00000126247
Uniprot IDs		P31785 Q5FC09	P04632
PDB IDs		1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7	1KFU 1KFX
Enriched GO Terms of Interacting Partners?		Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus	Negative Regulation Of Glycolytic Process Signal Transduction Response To Hypoxia Regulation Of Cell Death Cellular Response To Stimulus Signaling Cell Communication Temperature Homeostasis Regulation Of Glycolytic Process Response To Stimulus Regulation Of Apoptotic Process Response To Drug Positive Regulation Of Cell Cycle Process Cellular Response To Nitrite Response To Abiotic Stimulus Positive Regulation Of Cell Cycle Energy Derivation By Oxidation Of Organic Compounds Regulation Of Generation Of Precursor Metabolites And Energy Response To Organic Substance Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Interleukin-7-mediated Signaling Pathway Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Cellular Response To Organic Substance Response To Stress Mitotic Cell Cycle Positive Regulation Of Energy Homeostasis Response To Statin Telomeric Loop Formation Age-dependent Telomere Shortening Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Interleukin-8 Production Telomere Maintenance Via Telomere Shortening Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cellular Respiration Cellular Response To Oxygen Levels Respiratory Electron Transport Chain Response To Amino Acid Generation Of Precursor Metabolites And Energy Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process Cell Division Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Endomembrane System Organization
Tagcloud ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	afp buffalo cadaveric calpain cd34 curing facilitates fetoprotein greatest hcc hepatectomy hepatoma implantation invasiveness largest lungs microscopic microvessel modalities occult partial project regeneration remnant resection resections sizes transplantation vegfr2
Tagcloud (Difference) ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	afp buffalo cadaveric calpain cd34 curing facilitates fetoprotein greatest hcc hepatectomy hepatoma implantation invasiveness largest lungs microscopic microvessel modalities occult partial project regeneration remnant resection resections sizes transplantation vegfr2
Tagcloud (Intersection) ?