IL2RG and AXL

Number of citations of the paper that reports this interaction (PMID 16308569)
16

Data Source:
HPRD (in vivo)

		IL2RG	AXL
Gene Name		interleukin 2 receptor, gamma	AXL receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding	Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Spermatogenesis Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by VEGF VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	21 interactors: ADAM10 CBL FBXO25 GAS6 GRB2 IL15RA IL2RG LCK NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3
Entrez ID		3561	558
HPRD ID		02391	00171
Ensembl ID		ENSG00000147168	ENSG00000167601
Uniprot IDs		P31785 Q5FC09	M0R0W6 P30530
PDB IDs		1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7	2C5D
Enriched GO Terms of Interacting Partners?		Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Growth Factor Blood Coagulation Hemostasis Cellular Response To Organic Substance Response To Peptide Hormone Cellular Response To Organonitrogen Compound Locomotion Response To Organic Substance Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Insulin Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Cell Migration Wound Healing Movement Of Cell Or Subcellular Component Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Signal Transduction Cell Motility Response To Insulin Response To Wounding Regulation Of Phosphorylation Immune System Process Signaling Platelet Activation Cell Communication Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
Tagcloud ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Difference) ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Intersection) ?