IL2RG and KRTAP5-7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL2RG	KRTAP5-7
Description		interleukin 2 receptor subunit gamma	keratin associated protein 5-7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Cytosol Intermediate Filament
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Coreceptor Activity Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Protein Binding
	Biological Process	Mature B Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Lymphocyte Differentiation B Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Phagocytosis
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling	Keratinization
Drugs		Denileukin diftitox Aldesleukin Resatorvid
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Interacting Genes		27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	70 interacting genes: ADAMTSL3 ADAMTSL4 CARD9 CD300LG COL8A1 CRCT1 CREB5 CRY2 CYSRT1 DMRT3 DOCK2 FAM161A GUCD1 HHEX HOXB9 IGFBP6 IGSF8 IL2RG ITGB5 KPRP KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-4 KRTAP5-6 KRTAP9-2 LCE1A LCE1B LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3D LCE3E LCE4A MACO1 MAPKBP1 MRGBP MXI1 MYOM1 PHLDA1 PTPMT1 RAMP3 SAMD11 SCARF1 SDC3 SHFL SLC39A7 SMCP SPATA3 TRIM42 UXT WNT11 ZNF330 ZNF440 ZNF479 ZNF587 ZNF613
Entrez ID		3561	440050
HPRD ID		02391	17251
Ensembl ID		ENSG00000147168	ENSG00000244411
Uniprot IDs		H0Y8J6 P31785	Q6L8G8
PDB IDs		2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL 7S2R 8ENT 8EPA 9JQT
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Lymphocyte Differentiation Lymphocyte Activation Cell Surface Receptor Signaling Pathway Interleukin-4-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Interleukin-9-mediated Signaling Pathway Leukocyte Activation Regulation Of Hemopoiesis Lymphocyte Differentiation Cell Activation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Leukocyte Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Natural Killer Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Transduction Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Immune System Process B Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Immune System Process Natural Killer Cell Differentiation Regulation Of Immune System Process Natural Killer Cell Activation	Epidermis Development Keratinization Intermediate Filament Keratin Filament Tissue Development Hair Cycle Protein Binding
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