IL2RG and IL2RB

Number of citations of the paper that reports this interaction (PubMedID 11886175)
0

Data Source:
HPRD (in vivo)

		IL2RG	IL2RB
Description		interleukin 2 receptor subunit gamma	interleukin 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Endosome Cytosol Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Coreceptor Activity Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Cytokine Receptor Activity Interleukin-2 Receptor Activity Protein Binding Coreceptor Activity Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Mature B Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Lymphocyte Differentiation B Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Phagocytosis	Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling	RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		Denileukin diftitox Aldesleukin Resatorvid	Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Asthma ( 20860503 32296059) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)
Interacting Genes		27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	29 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MTDH PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TRIP13
Entrez ID		3561	3560
HPRD ID		02391	00896
Ensembl ID		ENSG00000147168	ENSG00000100385
Uniprot IDs		H0Y8J6 P31785	P14784
PDB IDs		2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL 7S2R 8ENT 8EPA 9JQT	2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K 7S2S
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Lymphocyte Differentiation Lymphocyte Activation Cell Surface Receptor Signaling Pathway Interleukin-4-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Interleukin-9-mediated Signaling Pathway Leukocyte Activation Regulation Of Hemopoiesis Lymphocyte Differentiation Cell Activation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Leukocyte Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Natural Killer Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Transduction Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Immune System Process B Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Immune System Process Natural Killer Cell Differentiation Regulation Of Immune System Process Natural Killer Cell Activation	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Multicellular Organismal Development Interleukin-15-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Leukocyte Activation Regulation Of Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Interleukin-2-mediated Signaling Pathway Regulation Of Lymphocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Lymphocyte Activation Cell Activation Positive Regulation Of Lymphocyte Differentiation Interleukin-9-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Cell Adhesion Cell Differentiation Mononuclear Cell Differentiation Regulation Of Cell Development Growth Hormone Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Differentiation Regulation Of Multicellular Organismal Process T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Signal Transduction Lymphocyte Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Proliferation Cellular Developmental Process Mononuclear Cell Proliferation Positive Regulation Of T Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Cell Differentiation Activated T Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?