IL2RG and IL7

Number of citations of the paper that reports this interaction (PubMedID 11858939)
0

Data Source:
HPRD (in vivo, in vitro)

		IL2RG	IL7
Description		interleukin 2 receptor subunit gamma	interleukin 7
Image
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Coreceptor Activity Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Cytokine Activity Cytokine Receptor Binding Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Mature B Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Lymphocyte Differentiation B Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Phagocytosis	Positive Regulation Of Cytokine-mediated Signaling Pathway T Cell Lineage Commitment Immune Response Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Organ Growth Interleukin-7-mediated Signaling Pathway B Cell Proliferation Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling	Interleukin-7 signaling Interleukin-7 signaling
Drugs		Denileukin diftitox Aldesleukin Resatorvid
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Blood protein levels ( 30072576) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Neutrophil percentage of white cells ( 27863252 32888494) Suicide in bipolar disorder ( 25917933)
Interacting Genes		27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	5 interacting genes: APP CEBPE FBXO7 IL2RG IL7R
Entrez ID		3561	3574
HPRD ID		02391	00892
Ensembl ID		ENSG00000147168	ENSG00000104432
Uniprot IDs		H0Y8J6 P31785	A0A0A0MTG5 A8K673 P13232 Q5FBX5
PDB IDs		2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL 7S2R 8ENT 8EPA 9JQT	3DI2 3DI3
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Lymphocyte Differentiation Lymphocyte Activation Cell Surface Receptor Signaling Pathway Interleukin-4-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Interleukin-9-mediated Signaling Pathway Leukocyte Activation Regulation Of Hemopoiesis Lymphocyte Differentiation Cell Activation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Leukocyte Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Natural Killer Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Transduction Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Immune System Process B Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Immune System Process Natural Killer Cell Differentiation Regulation Of Immune System Process Natural Killer Cell Activation	Mononuclear Cell Differentiation Leukocyte Differentiation Interleukin-7 Receptor Activity Leukocyte Activation Regulation Of Cell Activation Cell Activation Signaling Receptor Activator Activity Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Activation Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Lymphocyte Activation Hemopoiesis Cellular Developmental Process Regulation Of T Cell Differentiation In Thymus B Cell Activation Regulation Of Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Ephrin Receptor Binding Granulocyte Differentiation Regulation Of Lymphocyte Differentiation B Cell Homeostasis Regulation Of Monocyte Chemotaxis Lymphocyte Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Cell Development Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion B Cell Proliferation Positive Regulation Of Cell Differentiation T Cell Differentiation In Thymus Cytokine Receptor Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation External Side Of Plasma Membrane Positive Regulation Of Immune System Process Regulation Of Lymphocyte Apoptotic Process Lymphocyte Homeostasis Glial Cell Development Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of T Cell Activation Cell Differentiation Cytokine-mediated Signaling Pathway Amyloid-beta Complex Immune Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?