IL2RG and STK4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IL2RG	STK4
Gene Name		interleukin 2 receptor, gamma	serine/threonine kinase 4
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway	Cell Morphogenesis Patterning Of Blood Vessels Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	16 interactors: AKT1 CASP3 CNKSR1 CSN1S1 HIST2H2BE IL2RG LATS1 MBP NEDD4 PRKRIR RASSF1 RASSF5 SAV1 SGMS1 SIRT1 TP53
Entrez ID		3561	6789
HPRD ID		02391	05395
Ensembl ID		ENSG00000147168	ENSG00000101109
Uniprot IDs		P31785 Q5FC09	Q13043
PDB IDs		1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7	2JO8 3COM
Enriched GO Terms of Interacting Partners?		Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus	Response To Cytokine Positive Regulation Of Protein Metabolic Process Hippo Signaling Intracellular Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Helicase Activity Response To Stimulus Response To UV Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Aging Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Response To Radiation Response To Organic Substance Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Protein Kinase Activity Apoptotic Mitochondrial Changes Cellular Response To Stimulus Response To Stress Negative Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Apoptotic Process Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Programmed Cell Death Keratinocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Neuron Death Cell Death Cellular Response To Hypoxia Death Positive Regulation Of Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Autophagy Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Aging Cellular Response To Oxygen Levels Negative Regulation Of Cell Proliferation Response To Light Stimulus Apoptotic Signaling Pathway
Tagcloud ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Difference) ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Intersection) ?