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IL2RG and STK4
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
IL2RG
STK4
Description
interleukin 2 receptor subunit gamma
serine/threonine kinase 4
Image
GO Annotations
Cellular Component
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Body
Protein-containing Complex
Molecular Function
Cytokine Receptor Activity
Interleukin-2 Receptor Activity
Interleukin-4 Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
Coreceptor Activity
Cytokine Binding
Interleukin-2 Binding
Interleukin-15 Receptor Activity
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Biological Process
Mature B Cell Differentiation
CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
Immune System Process
Positive Regulation Of Immunoglobulin Production
Immune Response
Signal Transduction
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Cellular Homeostasis
Lymphocyte Differentiation
B Cell Differentiation
Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Phagocytosis
Cell Morphogenesis
Branching Involved In Blood Vessel Morphogenesis
Neural Tube Formation
Positive Regulation Of Protein Phosphorylation
Endocardium Development
Protein Phosphorylation
Protein Import Into Nucleus
Apoptotic Process
Signal Transduction
Central Nervous System Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Anatomical Structure Morphogenesis
Peptidyl-serine Phosphorylation
Keratinocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Organ Growth
Hippo Signaling
Positive Regulation Of Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Organ Growth
Protein Autophosphorylation
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Protein Stabilization
Protein Tetramerization
Canonical Wnt Signaling Pathway
Primitive Hemopoiesis
Cell Differentiation Involved In Embryonic Placenta Development
Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Negative Regulation Of Canonical Wnt Signaling Pathway
Hepatocyte Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
STAT3 nuclear events downstream of ALK signaling
Signaling by Hippo
Drugs
Denileukin diftitox
Aldesleukin
Resatorvid
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Bipolar disorder (
31043756
33263727
34002096
)
Mean platelet volume (
32888494
)
Platelet count (
32888494
)
Interacting Genes
27 interacting genes:
AXL
CAPNS1
ERRFI1
ICAM1
IL15
IL15RA
IL2
IL2RB
IL4
IL4R
IL7
IL7R
IL9R
JAK1
JAK3
KRTAP10-3
KRTAP10-8
KRTAP5-7
NOTCH2NLA
PTPRJ
SHB
SHC1
STAT1
STAT5A
STK4
WWP1
WWP2
25 interacting genes:
AKT1
CASP3
CNKSR1
CSN1S1
DAXX
DDIT4L
H2BC21
HSPA4
IL2RG
KEAP1
LATS1
MBP
NEDD4
OGT
PICK1
RASSF1
RASSF5
RNF31
RNF6
SAV1
SGMS1
SIRT1
THAP12
TP53
TRIM69
Entrez ID
3561
6789
HPRD ID
02391
05395
Ensembl ID
ENSG00000147168
ENSG00000101109
Uniprot IDs
H0Y8J6
P31785
A0A087WVN8
Q13043
PDB IDs
2B5I
2ERJ
3BPL
3QAZ
3QB7
4GS7
5M5E
6OEL
7S2R
8ENT
8EPA
9JQT
2JO8
3COM
4NR2
4OH8
5TWG
5TWH
6YAT
8A5J
8PAV
8PAW
Enriched GO Terms of Interacting Partners
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Cytokine-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Lymphocyte Differentiation
Lymphocyte Activation
Cell Surface Receptor Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Leukocyte Differentiation
Interleukin-9-mediated Signaling Pathway
Leukocyte Activation
Regulation Of Hemopoiesis
Lymphocyte Differentiation
Cell Activation
Interleukin-2-mediated Signaling Pathway
Positive Regulation Of Cell Activation
Regulation Of T Cell Differentiation
Cell Surface Receptor Signaling Pathway Via STAT
Mononuclear Cell Differentiation
Positive Regulation Of Lymphocyte Activation
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Leukocyte Differentiation
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell Development
Positive Regulation Of T Cell Differentiation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Differentiation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Cell Development
Positive Regulation Of Cell Differentiation
Regulation Of Cell-cell Adhesion
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Natural Killer Cell Differentiation
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Signal Transduction
Cytokine Receptor Activity
Regulation Of T-helper Cell Differentiation
Positive Regulation Of Immune System Process
B Cell Activation
Regulation Of Cell Differentiation
Regulation Of Cytokine Production
Immune System Process
Natural Killer Cell Differentiation
Regulation Of Immune System Process
Natural Killer Cell Activation
Apoptotic Process
Programmed Cell Death
Regulation Of Autophagy
Cell Death
Intracellular Signal Transduction
Regulation Of Macroautophagy
Response To Stress
Regulation Of Proteolysis
Identical Protein Binding
Regulation Of Protein Metabolic Process
Keratinocyte Differentiation
Positive Regulation Of Protein Metabolic Process
Response To UV
Immune System Process
Protein Modification Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Hippo Signaling
Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Protein Ubiquitination
Regulation Of Programmed Cell Death
Positive Regulation Of Proteolysis
Regulation Of Glucose Metabolic Process
Epidermal Cell Differentiation
Glial Cell Apoptotic Process
Regulation Of Programmed Necrotic Cell Death
PML Body
Keratin Filament Binding
Signal Transduction
Transcription Regulator Inhibitor Activity
Positive Regulation Of Metabolic Process
Regulation Of Endodeoxyribonuclease Activity
Nucleus
Regulation Of Post-translational Protein Modification
T Cell Differentiation In Thymus
Stress-induced Premature Senescence
Protein Ubiquitination
Post-translational Protein Modification
Cytoplasm
Regulation Of Hippo Signaling
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Nutrient Levels
Leukocyte Apoptotic Process
Cellular Response To Glucose Starvation
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Transcription By Glucose
Cellular Response To Decreased Oxygen Levels
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Negative Regulation Of Signaling
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Tagcloud (Difference)
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Tagcloud (Intersection)
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