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IL2RG and IL9R
Number of citations of the paper that reports this interaction (PubMedID
11418623
)
0
Data Source:
HPRD
(in vivo)
IL2RG
IL9R
Description
interleukin 2 receptor subunit gamma
interleukin 9 receptor
Image
GO Annotations
Cellular Component
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Extracellular Region
Extracellular Space
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Molecular Function
Cytokine Receptor Activity
Interleukin-2 Receptor Activity
Interleukin-4 Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
Coreceptor Activity
Cytokine Binding
Interleukin-2 Binding
Interleukin-15 Receptor Activity
Cytokine Receptor Activity
Interleukin-9 Receptor Activity
Interleukin-9 Binding
Biological Process
Mature B Cell Differentiation
CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
Immune System Process
Positive Regulation Of Immunoglobulin Production
Immune Response
Signal Transduction
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Cellular Homeostasis
Lymphocyte Differentiation
B Cell Differentiation
Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Phagocytosis
Signal Transduction
Immunoglobulin Mediated Immune Response
Cytokine-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
STAT3 nuclear events downstream of ALK signaling
Interleukin-9 signaling
Drugs
Denileukin diftitox
Aldesleukin
Resatorvid
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Interacting Genes
27 interacting genes:
AXL
CAPNS1
ERRFI1
ICAM1
IL15
IL15RA
IL2
IL2RB
IL4
IL4R
IL7
IL7R
IL9R
JAK1
JAK3
KRTAP10-3
KRTAP10-8
KRTAP5-7
NOTCH2NLA
PTPRJ
SHB
SHC1
STAT1
STAT5A
STK4
WWP1
WWP2
6 interacting genes:
CRADD
IL2RG
IL9
JAK1
KAT5
YWHAZ
Entrez ID
3561
3581
HPRD ID
02391
02052
Ensembl ID
ENSG00000147168
ENSG00000124334
Uniprot IDs
H0Y8J6
P31785
Q01113
PDB IDs
2B5I
2ERJ
3BPL
3QAZ
3QB7
4GS7
5M5E
6OEL
7S2R
8ENT
8EPA
9JQT
7OX5
Enriched GO Terms of Interacting Partners
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Cytokine-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Lymphocyte Differentiation
Lymphocyte Activation
Cell Surface Receptor Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Leukocyte Differentiation
Interleukin-9-mediated Signaling Pathway
Leukocyte Activation
Regulation Of Hemopoiesis
Lymphocyte Differentiation
Cell Activation
Interleukin-2-mediated Signaling Pathway
Positive Regulation Of Cell Activation
Regulation Of T Cell Differentiation
Cell Surface Receptor Signaling Pathway Via STAT
Mononuclear Cell Differentiation
Positive Regulation Of Lymphocyte Activation
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Leukocyte Differentiation
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell Development
Positive Regulation Of T Cell Differentiation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Differentiation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Cell Development
Positive Regulation Of Cell Differentiation
Regulation Of Cell-cell Adhesion
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Natural Killer Cell Differentiation
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Signal Transduction
Cytokine Receptor Activity
Regulation Of T-helper Cell Differentiation
Positive Regulation Of Immune System Process
B Cell Activation
Regulation Of Cell Differentiation
Regulation Of Cytokine Production
Immune System Process
Natural Killer Cell Differentiation
Regulation Of Immune System Process
Natural Killer Cell Activation
Interleukin-9-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
Cellular Response To Glucose Starvation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell-cell Adhesion
Signal Transduction
Cytokine-mediated Signaling Pathway
Immune Response
Interleukin-9 Receptor Binding
Histone H2AK5 Acetyltransferase Activity
B Cell Differentiation
Positive Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Interleukin-4 Receptor Activity
Interleukin-7 Receptor Activity
Protein Phosphatase Binding
Synaptic Target Recognition
Signal Transduction By P53 Class Mediator
Peptide Butyryltransferase Activity
Peptide 2-hydroxyisobutyryltransferase Activity
Peptide Crotonyltransferase Activity
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Interleukin-2 Binding
Interleukin-2 Receptor Activity
Interleukin-15 Receptor Activity
Death Domain Binding
Endopeptidase Complex
Histone H2A Acetyltransferase Activity
Peptide Lactyltransferase (CoA-dependent) Activity
Positive Regulation Of Multicellular Organismal Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Localization To Nucleus
CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
Piccolo Histone Acetyltransferase Complex
Intracellular Signal Transduction
Regulation Of Cell Adhesion
Receptor Complex
B Cell Activation
Positive Regulation Of Leukocyte Differentiation
Immune System Process
Regulation Of T Cell Differentiation
Cellular Response To Starvation
Golgi Reassembly
DNA-binding Transcription Factor Binding
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