IL2RG and IL15RA

Number of citations of the paper that reports this interaction (PMID 7641685)
96

Data Source:
HPRD (in vitro, in vivo)

		IL2RG	IL15RA
Gene Name		interleukin 2 receptor, gamma	interleukin 15 receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Nuclear Membrane
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding	Signal Transducer Activity Cytokine Receptor Activity Protein Binding
	Biological Process	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway	Signal Transduction Cell Proliferation Cytokine-mediated Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS			Asthma (bronchodilator response) ( 23508266) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	12 interactors: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		3561	3601
HPRD ID		02391	03045
Ensembl ID		ENSG00000147168	ENSG00000134470
Uniprot IDs		P31785 Q5FC09	G8CVM3 Q13261 Q3B769
PDB IDs		1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7	2ERS 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus	Positive Regulation Of Cell Activation Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Interleukin-2-mediated Signaling Pathway Signaling Cell Communication Regulation Of Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Cell-cell Adhesion Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Adhesion Regulation Of T Cell Activation Cellular Response To Nitric Oxide Response To Interleukin-2 Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Reactive Oxygen Species Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Differentiation Immune Response Response To Nitric Oxide Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Natural Killer Cell Differentiation Regulation Of Cell Death Positive Regulation Of Immune System Process Cellular Response To Reactive Nitrogen Species Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Lymphocyte Differentiation Response To Inorganic Substance Response To Stimulus Positive Regulation Of Natural Killer Cell Activation Regulation Of Intracellular Signal Transduction Positive Regulation Of Tissue Remodeling Response To Reactive Oxygen Species
Tagcloud ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7
Tagcloud (Difference) ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted	acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7
Tagcloud (Intersection) ?