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IL2RG and ICAM1
Number of citations of the paper that reports this interaction (PubMedID
1976256
)
33
Data Source:
HPRD
(in vivo)
IL2RG
ICAM1
Description
interleukin 2 receptor subunit gamma
intercellular adhesion molecule 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Immunological Synapse
Extracellular Space
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Extracellular Matrix
Membrane Raft
Extracellular Exosome
Molecular Function
Cytokine Receptor Activity
Interleukin-2 Receptor Activity
Interleukin-4 Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
Coreceptor Activity
Cytokine Binding
Interleukin-2 Binding
Interleukin-15 Receptor Activity
Virus Receptor Activity
Transmembrane Signaling Receptor Activity
Integrin Binding
Protein Binding
Signaling Receptor Activity
Biological Process
Mature B Cell Differentiation
CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
Immune System Process
Positive Regulation Of Immunoglobulin Production
Immune Response
Signal Transduction
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Cellular Homeostasis
Lymphocyte Differentiation
B Cell Differentiation
Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Phagocytosis
Regulation Of Leukocyte Mediated Cytotoxicity
Immune Effector Process
T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
T Cell Antigen Processing And Presentation
Positive Regulation Of Cellular Extravasation
Immune Response
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Membrane To Membrane Docking
Cell Adhesion Mediated By Integrin
Adhesion Of Symbiont To Host
Symbiont Entry Into Host Cell
Receptor-mediated Virion Attachment To Host Cell
Leukocyte Migration
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Glucose Stimulus
T Cell Extravasation
Cell-cell Adhesion
Regulation Of Ruffle Assembly
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Cellular Response To Amyloid-beta
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
STAT3 nuclear events downstream of ALK signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Drugs
Denileukin diftitox
Aldesleukin
Resatorvid
Natalizumab
Hyaluronic acid
Nafamostat
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
Allograft rejection
GWAS
Blood protein levels (
30072576
)
Crohn's disease (
21102463
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Low white blood cell count (conditioned on rs2814778) (
29596498
)
Lymphocyte count (
27863252
32888494
)
Monocyte count (
32888494
)
Pulse pressure (
27841878
)
Soluble ICAM-1 (
18604267
21533024
31217265
)
White blood cell count (
32888494
)
Interacting Genes
27 interacting genes:
AXL
CAPNS1
ERRFI1
ICAM1
IL15
IL15RA
IL2
IL2RB
IL4
IL4R
IL7
IL7R
IL9R
JAK1
JAK3
KRTAP10-3
KRTAP10-8
KRTAP5-7
NOTCH2NLA
PTPRJ
SHB
SHC1
STAT1
STAT5A
STK4
WWP1
WWP2
16 interacting genes:
CYSRT1
EGFR
EZR
FGG
HSD3B7
IL2RA
IL2RG
ITGAL
ITGAM
ITGB2
KEAP1
KRTAP10-8
MSN
SLC3A2
SPN
UBQLN2
Entrez ID
3561
3383
HPRD ID
02391
00996
Ensembl ID
ENSG00000147168
ENSG00000090339
Uniprot IDs
H0Y8J6
P31785
A0A384MEK5
P05362
PDB IDs
2B5I
2ERJ
3BPL
3QAZ
3QB7
4GS7
5M5E
6OEL
7S2R
8ENT
8EPA
9JQT
1D3E
1D3I
1D3L
1IAM
1IC1
1MQ8
1P53
1Z7Z
2OZ4
3TCX
5MZA
6EIT
6S8U
7BG7
Enriched GO Terms of Interacting Partners
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Cytokine-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Lymphocyte Differentiation
Lymphocyte Activation
Cell Surface Receptor Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Leukocyte Differentiation
Interleukin-9-mediated Signaling Pathway
Leukocyte Activation
Regulation Of Hemopoiesis
Lymphocyte Differentiation
Cell Activation
Interleukin-2-mediated Signaling Pathway
Positive Regulation Of Cell Activation
Regulation Of T Cell Differentiation
Cell Surface Receptor Signaling Pathway Via STAT
Mononuclear Cell Differentiation
Positive Regulation Of Lymphocyte Activation
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Leukocyte Differentiation
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell Development
Positive Regulation Of T Cell Differentiation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Differentiation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Cell Development
Positive Regulation Of Cell Differentiation
Regulation Of Cell-cell Adhesion
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Natural Killer Cell Differentiation
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Signal Transduction
Cytokine Receptor Activity
Regulation Of T-helper Cell Differentiation
Positive Regulation Of Immune System Process
B Cell Activation
Regulation Of Cell Differentiation
Regulation Of Cytokine Production
Immune System Process
Natural Killer Cell Differentiation
Regulation Of Immune System Process
Natural Killer Cell Activation
Cell Surface
Leukocyte Cell-cell Adhesion
Regulation Of Vesicle-mediated Transport
Cell Adhesion Molecule Binding
Cell Activation
External Side Of Plasma Membrane
Cell-cell Adhesion
Uropod
Leukocyte Activation
Integrin AlphaL-beta2 Complex
Integrin AlphaM-beta2 Complex
Microvillus
Cell-substrate Adhesion
Cell Adhesion
T Cell Activation
Interleukin-2 Binding
Interleukin-2 Receptor Activity
ICAM-3 Receptor Activity
Positive Regulation Of Neutrophil Degranulation
Integrin Complex
Positive Regulation Of Cell Adhesion
Gland Morphogenesis
Negative Regulation Of Dopamine Metabolic Process
Positive Regulation Of Metabolic Process
Cell-matrix Adhesion
Plasma Membrane Raft
Negative Regulation Of Catecholamine Metabolic Process
Membrane To Membrane Docking
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Transport
Regulation Of Developmental Process
Basolateral Plasma Membrane
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Neutrophil Degranulation
Regulation Of Multicellular Organismal Process
Lymphocyte Activation
Regulation Of ERK1 And ERK2 Cascade
Lymphocyte Migration
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Localization To Early Endosome
Regulation Of Immune System Process
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Macromolecule Metabolic Process
Complement Component C3b Binding
Heat Shock Protein Binding
Basal Plasma Membrane
Interleukin-2-mediated Signaling Pathway
Positive Regulation Of Protein Localization To Endosome
Positive Regulation Of Cell-cell Adhesion
Regulation Of Cell Adhesion
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