SF3B2 and SF3B4

Number of citations of the paper that reports this interaction (PMID 10490618)
38

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		SF3B2	SF3B4
Gene Name		splicing factor 3b, subunit 2, 145kDa	splicing factor 3b, subunit 4, 49kDa
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex
	Molecular Function	Protein Binding Poly(A) RNA Binding	Nucleotide Binding Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Viral Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Height ( 20881960 18391951)
Protein-Protein Interactions		25 interactors: APBB1 APP C7orf25 C8orf33 CSNK2A1 ERG FRA10AC1 HNRNPC KDM1A KIAA0368 LSM2 LSM3 PCBP2 PRPF40A RBM7 RBM8A SF3B4 SMAD3 SNRNP200 TCERG1 THOC1 TOE1 TTC14 U2AF1 ZCCHC10	42 interactors: APBB1 BAG3 BAIAP2 BMPR1A CHERP CWF19L2 DDX17 DDX42 EFTUD2 EWSR1 FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 MAPK9 METTL17 NCK2 NUB1 PPP1R16B PRPF40A RBM39 RBM4 SEC24D SF1 SF3B2 SRSF6 SS18L1 STK19 SUMO4 TCAF1 TCERG1 UBASH3A UBC WBP4 WDR77 ZCCHC10
Entrez ID		10992	10262
HPRD ID		10410	12028
Ensembl ID		ENSG00000087365	ENSG00000143368
Uniprot IDs		Q13435	B3KUJ0 Q15427
PDB IDs		2DO5	1X5T 1X5U
Enriched GO Terms of Interacting Partners?		RNA Processing MRNA Processing RNA Splicing MRNA Metabolic Process RNA Metabolic Process Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process MRNA Export From Nucleus Transcription, DNA-templated RNA Export From Nucleus RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of Cell Cycle RNA 3'-end Processing Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus Osteoblast Differentiation RNA Transport Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Regulation Of Gene Expression Negative Regulation Of Cell Cycle RNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Macromolecule Catabolic Process Metabolic Process Termination Of RNA Polymerase II Transcription Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process Negative Regulation Of Protein Metabolic Process Apoptotic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Thymidylate Synthase Biosynthetic Process Negative Regulation Of Potassium Ion Export Negative Regulation Of Isotype Switching To IgA Isotypes	RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Cellular Response To Growth Factor Stimulus Regulation Of ERBB Signaling Pathway Response To Growth Factor Negative Regulation Of Protein Metabolic Process Immune System Process Response To External Stimulus Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Signal Transduction Regulation Of Cellular Process Stress-activated MAPK Cascade Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process
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