SF3B2 and HNRNPC

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, biochemical, two hybrid, two hybrid)

		SF3B2	HNRNPC
Description		splicing factor 3b subunit 2	heterogeneous nuclear ribonucleoprotein C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly	MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Remodeling MRNA Processing RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase 3'-UTR-mediated MRNA Stabilization
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Metabolite levels ( 23823483)	Bipolar disorder ( 21738484 31043756) Height ( 31562340)
Interacting Genes		106 interacting genes: AKAP9 APBB1 APP C7orf25 C8orf33 CASK CSNK2A1 ECPAS ERG FMR1 FRA10AC1 FXR1 FXR2 HNRNPC KDM1A LSM2 LSM3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PCBP2 PRC1 PRKN PRPF40A RBM10 RBM11 RBM7 RBM8A RNF10 SF3B4 SMAD3 SUMO2 TCERG1 THOC1 TOE1 TTC14 U2AF1 USP7 WBP4 ZCCHC10	59 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 DLG4 EPS8 ERG ESR1 FAS FXR2 GRB2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MAPT MEOX2 NUFIP2 OGT PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALYL RBM41 RBPMS2 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I USP7 WEE2-AS1 YWHAE YWHAQ ZFYVE26 ZNF581
Entrez ID		10992	3183
HPRD ID		10410	01243
Ensembl ID		ENSG00000087365	ENSG00000092199
Uniprot IDs		Q13435	P07910
PDB IDs		2DO5 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI 7DVQ 7EVO 7ONB 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	1TXP 1WF2 2MXY 2MZ1 3LN4
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Nuclear Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of RNA Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Regulation Of Cell Communication Regulation Of Signaling BRCA1-B Complex DNA Metabolic Process DNA Repair DNA Recombination Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Nuclear Body Organization Double-strand Break Repair Via Homologous Recombination Regulation Of Macromolecule Biosynthetic Process Recombinational Repair Nuclear Import Signal Receptor Activity Cytosol Regulation Of DNA Metabolic Process Nuclear Localization Sequence Binding Regulation Of Cell Cycle Process Regulation Of DNA Damage Checkpoint Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus Regulation Of Cellular Response To Stress Cellular Component Assembly PML Body Cytoplasm Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus
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