SF3B2 and TOE1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		SF3B2	TOE1
Description		splicing factor 3b subunit 2	target of EGR1, exonuclease
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Protein Binding Zinc Ion Binding SnRNA Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly	RNA Metabolic Process SnRNA 3'-end Processing
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Metabolite levels ( 23823483)
Interacting Genes		106 interacting genes: AKAP9 APBB1 APP C7orf25 C8orf33 CASK CSNK2A1 ECPAS ERG FMR1 FRA10AC1 FXR1 FXR2 HNRNPC KDM1A LSM2 LSM3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PCBP2 PRC1 PRKN PRPF40A RBM10 RBM11 RBM7 RBM8A RNF10 SF3B4 SMAD3 SUMO2 TCERG1 THOC1 TOE1 TTC14 U2AF1 USP7 WBP4 ZCCHC10	27 interacting genes: ABCF3 AGGF1 ANXA1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 OGT PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		10992	114034
HPRD ID		10410	18212
Ensembl ID		ENSG00000087365	ENSG00000132773
Uniprot IDs		Q13435	B4DP23 Q96GM8
PDB IDs		2DO5 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI 7DVQ 7EVO 7ONB 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	2FC6
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Spliceosomal Complex MRNA Processing MRNA Metabolic Process Catalytic Step 2 Spliceosome RNA Metabolic Process Nucleoplasm Nuclear Speck Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Macromolecule Metabolic Process U2-type Precatalytic Spliceosome Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Regulation Of MRNA Processing Glutamatergic Synapse Cadherin Binding Involved In Cell-cell Adhesion RNA Binding Transition Metal Ion Binding U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP Membraneless Organelle Assembly U2-type Spliceosomal Complex Regulation Of Programmed Cell Death Alpha-2B Adrenergic Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Synaptic Vesicle Priming Oocyte Axis Specification
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