SLC8A3 and PPP3CB

Number of citations of the paper that reports this interaction (PMID 15557343)
10

Data Source:
HPRD (in vivo)

		SLC8A3	PPP3CB
Gene Name		solute carrier family 8 (sodium/calcium exchanger), member 3	protein phosphatase 3, catalytic subunit, beta isozyme
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Microtubule Plasma Membrane Integral Component Of Membrane Sarcolemma Neuronal Cell Body Dendritic Spine	Nucleoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule
	Molecular Function	Calcium:sodium Antiporter Activity Calmodulin Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Ion Transport Cell Communication Blood Coagulation Telencephalon Development Sodium Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Cellular Response To CAMP Calcium Ion Export From Cell Calcium Ion Import Into Cell	Negative Regulation Of T Cell Mediated Cytotoxicity Protein Phosphorylation Protein Dephosphorylation Signal Transduction Heart Development Learning Memory Dephosphorylation Calcium Ion-dependent Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Social Behavior Cellular Response To Drug Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Positive Regulation Of NFAT Protein Import Into Nucleus
Pathways		Sodium/Calcium exchangers Platelet homeostasis Reduction of cytosolic Ca++ levels Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Platelet calcium homeostasis	Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Corneal curvature ( 22969067) Cystic fibrosis severity ( 21602797)
Protein-Protein Interactions		4 interactors: PPP3CB YWHAB YWHAE YWHAQ	12 interactors: CABIN1 IRAK1 IRF2 JUN MARCH7 MYOZ2 MYOZ3 NFATC2 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		6547	5532
HPRD ID		09723	00235
Ensembl ID		ENSG00000100678	ENSG00000107758
Uniprot IDs		B3KU59 P57103	P16298
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Regulation Of Mitochondrion Organization Negative Regulation Of Protein Dephosphorylation Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Localization Hippo Signaling Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Organelle Organization Protein Targeting Neural Nucleus Development Intracellular Signal Transduction Negative Regulation Of Dephosphorylation Establishment Of Localization In Cell Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Midbrain Development Nervous System Development Cellular Localization Regulation Of Dephosphorylation Membrane Organization Intracellular Protein Transport Regulation Of Organelle Organization Apoptotic Process Regulation Of Signaling Programmed Cell Death Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone Cell Death Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Cellular Protein Localization Fc Receptor Signaling Pathway Protein Transport Regulation Of Apoptotic Process Establishment Of Protein Localization	Calcium Ion Export Response To Wounding Innate Immune Response Response To Organonitrogen Compound Response To Stress Blood Coagulation Hemostasis Response To Purine-containing Compound Cellular Response To Organic Substance Cell Communication Sodium Ion Transmembrane Transport Regulation Of Body Fluid Levels Calcium Ion Import Calcium Ion Transmembrane Transport Wound Healing Immune Response Regulation Of Innate Immune Response Immune System Process Sodium Ion Transport Defense Response Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Response To Cytokine Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Toll-like Receptor TLR1:TLR2 Signaling Pathway Calcium Ion Transport Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Cellular Response To Potassium Ion Starvation MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Calcium Ion Import Into Cell Calcium Ion Export From Cell Leading Edge Cell Differentiation Sodium Ion Import Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Cytokine-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Immune Response-regulating Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon
Tagcloud ?			actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled
Tagcloud (Difference) ?			actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled
Tagcloud (Intersection) ?