SLC8A3 and PPP3CB

Number of citations of the paper that reports this interaction (PubMedID 15557343)
0

Data Source:
HPRD (in vivo)

		SLC8A3	PPP3CB
Description		solute carrier family 8 member A3	protein phosphatase 3 catalytic subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Dendrite Neuromuscular Junction Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Postsynapse	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Z Disc T-tubule Glutamatergic Synapse
	Molecular Function	Calcium:sodium Antiporter Activity Protein Binding Calmodulin Binding Antiporter Activity Calcium:monoatomic Cation Antiporter Activity Metal Ion Binding Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Intracellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Skeletal Muscle Contraction Telencephalon Development Metal Ion Transport Sodium Ion Transmembrane Transport Myelination Oligodendrocyte Differentiation Synapse Organization Mitochondrial Calcium Ion Homeostasis Transmembrane Transport Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Hypoxia Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane	T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Response To Stress Lysosome Organization Signal Transduction Heart Development Learning Memory Regulation Of Gene Expression Dephosphorylation Calcium-ion Regulated Exocytosis Negative Regulation Of Signaling T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Skeletal Muscle Fiber Development Regulation Of Insulin Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Lysosome Organization Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Mitochondrial calcium ion transport	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Corneal curvature ( 22969067) Cystic fibrosis severity ( 21602797) Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: GJA8 PPP3CB YWHAB YWHAE YWHAQ	20 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 RCAN1 ROR2 RUNX1 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		6547	5532
HPRD ID		09723	00235
Ensembl ID		ENSG00000100678	ENSG00000107758
Uniprot IDs		B3KU59 P57103	B7Z781 P16298
PDB IDs			4OR9 4ORA 4ORC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Monoatomic Ion Transport Phosphoserine Residue Binding Negative Regulation Of Transmembrane Transport Protein Targeting Protein Domain Specific Binding Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Phosphoprotein Binding Protein Phosphatase Inhibitor Activity Protein Sequestering Activity Substantia Nigra Development Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Calcium Ion Transport Enzyme Binding Regulation Of Monoatomic Ion Transport Neural Nucleus Development Focal Adhesion Regulation Of Protein Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Regulation Of Transport Melanosome Regulation Of Nucleocytoplasmic Transport Histone Deacetylase Binding Regulation Of Heart Rate By Hormone Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Protein Localization To Nucleus Positive Regulation Of Lysosome Organization Intracellular Signaling Cassette Calmodulin-dependent Protein Phosphatase Activity Regulation Of Protein Localization Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization Gap Junction-mediated Intercellular Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Calcium Ion Transport Calcineurin Complex Regulation Of Calcium Ion Export Across Plasma Membrane Locomotion Involved In Locomotory Behavior Positive Regulation Of Protein Transport Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Phosphatase 2B Binding Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Intracellular Transport	Calcium:sodium Antiporter Activity Eyelid Development In Camera-type Eye Striated Muscle Cell Development Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Regulation Of Cardiac Conduction Muscle Cell Development Regulation Of Signal Transduction Calcium Ion Import Regulation Of Calcineurin-mediated Signaling Calcium Ion Export Across Plasma Membrane FATZ Binding Negative Regulation Of Signal Transduction Protein Phosphatase Inhibitor Activity Transcription Factor AP-1 Complex Protein Kinase Activity Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Telethonin Binding Axon Terminus Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Export Across Plasma Membrane Neuronal Cell Body Axon Negative Regulation Of Cardiocyte Differentiation Calcium Ion Transport Into Cytosol Negative Regulation Of Calcineurin-NFAT Signaling Cascade Calcium Ion Transmembrane Import Into Cytosol Cellular Developmental Process Regulation Of Calcium-mediated Signaling Inorganic Cation Import Across Plasma Membrane Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Synapse Organization Postsynaptic Density Transcription Cis-regulatory Region Binding Calcineurin-NFAT Signaling Cascade Learning Or Memory Regulation Of Intracellular Signal Transduction Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Sarcolemma Memory Intracellular Signaling Cassette Response To Muscle Stretch Coronary Vasculature Development
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