SLC8A3

Gene Name		solute carrier family 8 (sodium/calcium exchanger), member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Microtubule Plasma Membrane Integral Component Of Membrane Sarcolemma Neuronal Cell Body Dendritic Spine
	Molecular Function	Calcium:sodium Antiporter Activity Calmodulin Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Ion Transport Cell Communication Blood Coagulation Telencephalon Development Sodium Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Cellular Response To CAMP Calcium Ion Export From Cell Calcium Ion Import Into Cell
Pathways		Sodium/Calcium exchangers Platelet homeostasis Reduction of cytosolic Ca++ levels Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Platelet calcium homeostasis
Drugs
Diseases
GWAS		Corneal curvature ( 22969067) Cystic fibrosis severity ( 21602797)
Protein-protein Interactions		4 interactors: PPP3CB YWHAB YWHAE YWHAQ
Entrez ID		6547
HPRD ID		09723
Ensembl ID		ENSG00000100678
Uniprot IDs		B3KU59 P57103
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Regulation Of Mitochondrion Organization Negative Regulation Of Protein Dephosphorylation Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Localization Hippo Signaling Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Organelle Organization Protein Targeting Neural Nucleus Development Intracellular Signal Transduction Negative Regulation Of Dephosphorylation Establishment Of Localization In Cell Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Midbrain Development Nervous System Development Cellular Localization Regulation Of Dephosphorylation Membrane Organization Intracellular Protein Transport Regulation Of Organelle Organization Apoptotic Process Regulation Of Signaling Programmed Cell Death Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone Cell Death Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Cellular Protein Localization Fc Receptor Signaling Pathway Protein Transport Regulation Of Apoptotic Process Establishment Of Protein Localization
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