DAB2IP and MAP3K5

Number of citations of the paper that reports this interaction (PubMedID 12813029)
30

Data Source:
HPRD (in vivo, two hybrid)

		DAB2IP	MAP3K5
Description		DAB2 interacting protein	mitogen-activated protein kinase kinase kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Axon Dendrite Neuronal Cell Body Membrane Cell Projection Neuronal Cell Body Cerebellar Mossy Fiber Climbing Fiber Parallel Fiber AIP1-IRE1 Complex	Cytoplasm Endoplasmic Reticulum Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	GTPase Activator Activity Death Receptor Binding Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Phosphatidylinositol-3-phosphate Binding Signaling Adaptor Activity Toll-like Receptor 4 Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Protein-containing Complex Binding Cadherin Binding Protein Phosphatase 2A Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Immune System Process Apoptotic Process Inflammatory Response Response To Unfolded Protein Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Protein Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of GTPase Activity Cellular Response To Unfolded Protein Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Fibroblast Proliferation Neuron Projection Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synapse Maturation Lipid Droplet Formation Positive Regulation Of Dendrite Development Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Migration Positive Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Immune System Process Response To Ischemia Apoptotic Process JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Neuron Apoptotic Process Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Regulation of RAS by GAPs	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 20622881 27899403) Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Appendicular lean mass ( 33097823) Arterial stiffness index ( 31235810) Coronary artery disease ( 33020668 32469254 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Heart rate ( 23534349) Hip index ( 34021172) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Myocardial infarction ( 33532862) Periodontal microbiota ( 22699663) Squamous cell lung carcinoma ( 31326317) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Eosinophil count ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: AKT1 DAB1 DAB2 MAP3K5 SMARCA2 YWHAQ	69 interacting genes: AKT1 ARRB2 AURKA BIRC2 CCND2 CDC25A CDC25C CDK4 CDK6 CDKN1A CDKN2A CIB1 CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PRMT1 PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNFAIP8L1 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		153090	4217
HPRD ID		09903	03904
Ensembl ID		ENSG00000136848	ENSG00000197442
Uniprot IDs		Q5VWQ8	A0A8V8TMH5 Q99683
PDB IDs			2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH 7MU6 7MU7 8QGY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Negative Regulation Of Cell Projection Organization Regulation Of Cell Adhesion Regulation Of Cell Differentiation 14-3-3 Protein Binding Positive Regulation Of Steroid Biosynthetic Process Intracellular Signaling Cassette Positive Regulation Of Steroid Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Myoblast Differentiation Response To Epidermal Growth Factor Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Developmental Process Regulation Of Steroid Biosynthetic Process Regulation Of Cell Growth Regulation Of Neuron Projection Development Regulation Of TRNA Methylation Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Myoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Growth Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Insulin-like Growth Factor Stimulus Regulation Of DNA-templated Transcription Mammalian Oogenesis Stage Regulation Of Ketone Metabolic Process Nervous System Development Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Adhesion TRNA (guanine-N7)-methylation Response To Tumor Necrosis Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Lipid Transport Cellular Response To Rapamycin Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Cellular Response To Tumor Necrosis Factor	Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Signal Transduction Cytosol Cytoplasm Positive Regulation Of MAPK Cascade Cellular Response To Stress Regulation Of Protein Metabolic Process MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of Apoptotic Process Protein Kinase Binding Protein Modification Process Positive Regulation Of Protein Metabolic Process Transferase Activity Enzyme Binding Regulation Of Primary Metabolic Process Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Metabolic Process Protein Serine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of JNK Cascade Kinase Activity Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Catalytic Activity Identical Protein Binding Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Protein Metabolic Process Regulation Of Innate Immune Response
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