DAB2IP and MAP3K5

Number of citations of the paper that reports this interaction (PMID 12813029)
31

Data Source:
HPRD (in vivo, two hybrid)

		DAB2IP	MAP3K5
Gene Name		DAB2 interacting protein	mitogen-activated protein kinase kinase kinase 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Endocytic Vesicle Axon Dendrite Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Neuronal Cell Body Membrane Neuronal Cell Body Cerebellar Mossy Fiber Climbing Fiber Extracellular Vesicular Exosome Parallel Fiber	Endoplasmic Reticulum Cytosol Protein Kinase Complex
	Molecular Function	Ras GTPase Activator Activity Death Receptor Binding Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Phosphatidylinositol-3-phosphate Binding Protein Complex Binding Signaling Adaptor Activity Toll-like Receptor 4 Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Phosphatidylinositol 3-kinase Binding Protein Phosphatase 2A Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding	Magnesium Ion Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKKK Activity Angiogenesis Negative Regulation Of Protein Phosphorylation Transformed Cell Apoptotic Process Inflammatory Response Response To Unfolded Protein Cell Cycle I-kappaB Phosphorylation Activation Of JUN Kinase Activity Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of ARF GTPase Activity Positive Regulation Of Ras GTPase Activity Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Ras GTPase Activity Tube Formation Negative Regulation Of Catenin Import Into Nucleus Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Reelin-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Fibroblast Proliferation Neuron Projection Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Cycle Arrest Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synapse Maturation Positive Regulation Of Dendrite Development Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cyclin Catabolic Process Positive Regulation Of Neuron Migration Positive Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Viral Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 20622881) Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Heart rate ( 23534349) Periodontal microbiota ( 22699663) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		5 interactors: AKT1 DAB1 DAB2 MAP3K5 YWHAQ	50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		153090	4217
HPRD ID		09903	03904
Ensembl ID		ENSG00000136848	ENSG00000197442
Uniprot IDs		Q5VWQ8	Q99683
PDB IDs			2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of JNK Cascade Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Programmed Cell Death Positive Regulation Of Proteolysis Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Death Regulation Of Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Localization To Plasma Membrane Regulation Of Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Death Regulation Of JUN Kinase Activity JNK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of Cell Adhesion	Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Apoptotic Process Positive Regulation Of Transferase Activity Programmed Cell Death Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Cell Death Death Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Stimulus Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Cell Death Signal Transduction Signaling Positive Regulation Of Cell Death
Tagcloud ?		al chronic cytoplasm dependent di et induces inflammation interacts issue jnk kb link minin mutant mutp53 nf p53 profile progression signaling suppressor tnf transcriptional tumor tumorigenic via	199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
Tagcloud (Difference) ?		al chronic cytoplasm dependent di et induces inflammation interacts issue jnk kb link minin mutant mutp53 nf p53 profile progression signaling suppressor tnf transcriptional tumor tumorigenic via	199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
Tagcloud (Intersection) ?