DAB2IP

Gene Name		DAB2 interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Endocytic Vesicle Axon Dendrite Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Neuronal Cell Body Membrane Neuronal Cell Body Cerebellar Mossy Fiber Climbing Fiber Extracellular Vesicular Exosome Parallel Fiber
	Molecular Function	Ras GTPase Activator Activity Death Receptor Binding Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Phosphatidylinositol-3-phosphate Binding Protein Complex Binding Signaling Adaptor Activity Toll-like Receptor 4 Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Phosphatidylinositol 3-kinase Binding Protein Phosphatase 2A Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKKK Activity Angiogenesis Negative Regulation Of Protein Phosphorylation Transformed Cell Apoptotic Process Inflammatory Response Response To Unfolded Protein Cell Cycle I-kappaB Phosphorylation Activation Of JUN Kinase Activity Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of ARF GTPase Activity Positive Regulation Of Ras GTPase Activity Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Ras GTPase Activity Tube Formation Negative Regulation Of Catenin Import Into Nucleus Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Reelin-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Fibroblast Proliferation Neuron Projection Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Cycle Arrest Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synapse Maturation Positive Regulation Of Dendrite Development Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cyclin Catabolic Process Positive Regulation Of Neuron Migration Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 20622881) Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Heart rate ( 23534349) Periodontal microbiota ( 22699663) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-protein Interactions		5 interactors: AKT1 DAB1 DAB2 MAP3K5 YWHAQ
Entrez ID		153090
HPRD ID		09903
Ensembl ID		ENSG00000136848
Uniprot IDs		Q5VWQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of JNK Cascade Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Programmed Cell Death Positive Regulation Of Proteolysis Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Death Regulation Of Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Localization To Plasma Membrane Regulation Of Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Death Regulation Of JUN Kinase Activity JNK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of Cell Adhesion
Tagcloud ?		al chronic cytoplasm dependent di et induces inflammation interacts issue jnk kb link minin mutant mutp53 nf p53 profile progression signaling suppressor tnf transcriptional tumor tumorigenic via