CD40 and JAK3

Number of citations of the paper that reports this interaction (PubMedID 10395671)
0

Data Source:
HPRD (in vitro)

		CD40	JAK3
Description		CD40 molecule	Janus kinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Endosome Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding
	Biological Process	Immune System Process Regulation Of Immunoglobulin Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Bacterium Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Response To Nutrient Levels Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Type II Interferon Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process	Adaptive Immune Response Immune System Process Negative Regulation Of Dendritic Cell Cytokine Production Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Cell Differentiation B Cell Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment
Pathways			Interleukin-7 signaling Interleukin-7 signaling Signaling by ALK RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling Potential therapeutics for SARS
Drugs		Lucatumumab Dacetuzumab	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one R-348 Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Zanubrutinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233 28067908) Kawasaki disease ( 33106546 22446961 22446962) Multiple sclerosis ( 19525955 24076602 22190364 21833088) Rheumatoid arthritis ( 24390342 23143596 30423114 18794853) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)
Interacting Genes		44 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MIP MS4A1 NCOA6 NSMAF PIK3R1 PLP1 RIPK2 SLC30A2 SLC30A3 SLC39A13 SLC61A1 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	43 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CISH CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B UHRF2 VIL1
Entrez ID		958	3718
HPRD ID		00178	02547
Ensembl ID		ENSG00000101017	ENSG00000105639
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 A0A8Q3SI60 P25942 Q6P2H9	P52333
PDB IDs		1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9 7P3I 8YX1 8YX9	1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4 7APF 7APG 7C3N 7Q6H 7UYV 8EXM
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway CD40 Receptor Complex Tumor Necrosis Factor Receptor Binding Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Response To Stress Regulation Of Immune Response Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Response To Other Organism Positive Regulation Of Post-translational Protein Modification Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Defense Response Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Immune System Process Immune Response Positive Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Toll-like Receptor 4 Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin Protein Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Protein Binding CD40 Receptor Binding Defense Response To Other Organism Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Activation Immune System Process Regulation Of Programmed Cell Death Response To External Biotic Stimulus Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of DNA-binding Transcription Factor Activity	Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Activation Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Regulation Of Cell Development Regulation Of Developmental Process Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Lymphocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Via STAT T Cell Activation Lymphocyte Mediated Immunity Regulation Of Immune Response Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Mononuclear Cell Differentiation Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Differentiation Immune System Process B Cell Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Cell Development Leukocyte Mediated Immunity Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Apoptotic Process Leukocyte Differentiation
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