Wiki-Pi
About
Search
People
Updates
Search
CD40 and CAV1
Number of citations of the paper that reports this interaction (PubMedID
14665433
)
0
Data Source:
HPRD
(in vivo)
CD40
CAV1
Description
CD40 molecule
caveolin 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
CD40 Receptor Complex
Neuronal Cell Body
Varicosity
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Golgi Membrane
Acrosomal Membrane
Caveolar Macromolecular Signaling Complex
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Lipid Droplet
Plasma Membrane
Caveola
Focal Adhesion
Cilium
Cell Cortex
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Antigen Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Signaling Receptor Binding
Patched Binding
Protein Binding
Oxysterol Binding
Cholesterol Binding
Peptidase Activator Activity
Enzyme Binding
Protein Kinase Binding
Protein Tyrosine Kinase Inhibitor Activity
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Nitric-oxide Synthase Inhibitor Activity
Identical Protein Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Protein Heterodimerization Activity
Nitric-oxide Synthase Binding
ATPase Binding
Molecular Adaptor Activity
Inward Rectifier Potassium Channel Inhibitor Activity
Protein Sequestering Activity
Biological Process
Immune System Process
Regulation Of Immunoglobulin Production
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Calcium Ion Homeostasis
Defense Response
Inflammatory Response
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Bacterium
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
B Cell Mediated Immunity
CD40 Signaling Pathway
Platelet Activation
Positive Regulation Of B Cell Proliferation
Response To Nutrient Levels
Positive Regulation Of Interleukin-12 Production
Response To Cobalamin
Response To Type II Interferon
Cellular Response To Erythropoietin
B Cell Proliferation
B Cell Activation
Defense Response To Protozoan
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Immune Response
Positive Regulation Of Developmental Process
Positive Regulation Of Multicellular Organismal Process
Defense Response To Virus
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Kinase C Signaling
Response To Peptide
Positive Regulation Of Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Angiogenesis
Vasculogenesis
Response To Hypoxia
Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of The Force Of Heart Contraction
Glandular Epithelial Cell Differentiation
Response To Ischemia
Regulation Of The Force Of Heart Contraction By Chemical Signal
Triglyceride Metabolic Process
Nitric Oxide Biosynthetic Process
Calcium Ion Transport
Intracellular Calcium Ion Homeostasis
Regulation Of Smooth Muscle Contraction
Skeletal Muscle Tissue Development
Lactation
Intracellular Protein Localization
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Response To Bacterium
Negative Regulation Of Signal Transduction
Positive Regulation Of Calcium Ion Transport Into Cytosol
Post-transcriptional Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Positive Regulation Of Cholesterol Efflux
Protein Transport
Vesicle Organization
Receptor-mediated Endocytosis Of Virus By Host Cell
Regulation Of Fatty Acid Metabolic Process
Cytokine-mediated Signaling Pathway
Lipid Storage
Cell Differentiation
Regulation Of Blood Coagulation
Cholesterol Transport
Positive Regulation Of Cell Migration
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Receptor Internalization
Maintenance Of Protein Location In Cell
Response To Progesterone
Intracellular Nitric Oxide Homeostasis
Toll-like Receptor 4 Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Insulin Receptor Internalization
Angiotensin-activated Signaling Pathway
Vasoconstriction
Cholesterol Homeostasis
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of MAPK Cascade
Response To Estrogen
Protein Localization To Plasma Membrane Raft
Negative Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Vasoconstriction
Nitric Oxide Metabolic Process
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Muscle Cell Cellular Homeostasis
Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Negative Regulation Of Pinocytosis
Regulation Of Cytosolic Calcium Ion Concentration
Response To Calcium Ion
Establishment Of Localization In Cell
Membrane Depolarization
Calcium Ion Homeostasis
Mammary Gland Involution
Canonical Wnt Signaling Pathway
Negative Regulation Of Necroptotic Process
Caveola Assembly
Cellular Response To Misfolded Protein
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Hyperoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
Basement Membrane Organization
Caveolin-mediated Endocytosis
Regulation Of Heart Rate By Cardiac Conduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Apoptotic Signaling Pathway
Regulation Of Membrane Repolarization During Action Potential
Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Ruffle Assembly
Negative Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Protein Localization To Basolateral Plasma Membrane
Positive Regulation Of Gap Junction Assembly
Positive Regulation Of ERAD Pathway
Regulation Of Entry Of Bacterium Into Host Cell
Negative Regulation Of Anoikis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Triglyceride catabolism
eNOS activation
NOSTRIN mediated eNOS trafficking
Thyroxine biosynthesis
Basigin interactions
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
FOXO-mediated transcription of cell cycle genes
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs
Lucatumumab
Dacetuzumab
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
Congenital generalized lipodystrophy (CGL)
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Chronic hepatitis B infection (
25802187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
23128233
28067908
)
Kawasaki disease (
33106546
22446961
22446962
)
Multiple sclerosis (
19525955
24076602
22190364
21833088
)
Rheumatoid arthritis (
24390342
23143596
30423114
18794853
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Systemic lupus erythematosus (
28714469
)
Tonsillectomy (
27182965
28928442
)
Atrial fibrillation (
33990960
22544366
30061737
29892015
28416822
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
20062063
25055868
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (
30054594
)
Glaucoma (primary open-angle) (
25173105
29891935
33627673
20835238
)
Heart rate increase in response to exercise (
29497042
)
Heart rate response to recovery post exercise (10 sec) (
29497042
)
Heart rate response to recovery post exercise (20 sec) (
29497042
)
Heart rate response to recovery post exercise (30 sec) (
29497042
)
Heart rate response to recovery post exercise (40 sec) (
29497042
)
Heart rate response to recovery post exercise (50 sec) (
29497042
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
27863252
32888494
)
Intraocular pressure (
29235454
25173106
28073927
29617998
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte percentage of white cells (
32888494
)
P wave duration (
28794112
)
Platelet distribution width (
32888494
)
PR interval (
20062060
25035420
32439900
30679814
23139255
30046033
29127183
)
PR segment duration (
24850809
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
QRS duration (
30012220
)
QT interval (
29874175
24952745
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Interacting Genes
44 interacting genes:
BIRC2
BIRC3
CAV1
CBL
CD40LG
CMTM5
CMTM6
CYB561A3
DEFB121
EBP
FAF1
HSPA4
HSPA8
IL4R
INSIG2
JAK3
MAL
MAP3K8
MIP
MS4A1
NCOA6
NSMAF
PIK3R1
PLP1
RIPK2
SLC30A2
SLC30A3
SLC39A13
SLC61A1
SLC7A1
TANK
TDP2
TLCD1
TMEM107
TMEM128
TMEM147
TRAF1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRAF6
XRCC5
XRCC6
86 interacting genes:
ABCB1
ABL1
AKAP1
APP
AR
BMX
BSG
BST1
BTK
CAV2
CD40
CSK
CSNK2A1
CSNK2A2
DAG1
DANCR
DNM1
EDNRB
EGFR
ERBB2
ESR1
FLNA
FLOT2
FYN
GJA1
GJA3
GJB2
GLP1R
GNAI2
GRB7
GRK1
GRK2
GRK5
HRAS
HTR1F
IGF1R
IGFBP3
ILK
INSR
IRS1
KCNA3
KDR
LRP1
MALL
MAPK1
MAPK3
MMP14
NEU3
NGFR
NOS2
NOS3
NTRK1
PDGFRA
PDGFRB
PLD1
PLD2
PPP1CA
PPP2CA
PRNP
PTEN
PTGS2
PTPN1
PTPN11
PTPN6
PTPRF
RAC1
RCVRN
RHOA
RHOC
S1PR1
SCP2
SNCA
SOS1
SRC
STOML3
STRN
STRN4
TEK
TGFBR1
TNFRSF1B
TRAF2
TRAF4
TRAF6
TRPC1
USP7
VAV2
Entrez ID
958
857
HPRD ID
00178
03028
Ensembl ID
ENSG00000101017
ENSG00000105974
Uniprot IDs
A0A0S2Z349
A0A0S2Z3C7
A0A8Q3SI60
P25942
Q6P2H9
A9XTE5
Q03135
Q2TNI1
Q59E85
Q7Z4F3
PDB IDs
1CZZ
1D00
1FLL
1LB6
3QD6
5DMI
5DMJ
5IHL
6FAX
6PE8
6PE9
7P3I
8YX1
8YX9
7SC0
Enriched GO Terms of Interacting Partners
?
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Signaling Pathway
CD40 Receptor Complex
Tumor Necrosis Factor Receptor Binding
Thioesterase Binding
Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Signaling Adaptor Activity
Cell Surface Receptor Signaling Pathway
Response To Stress
Regulation Of Immune Response
Regulation Of Innate Immune Response
Cytoplasmic Side Of Plasma Membrane
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Protein Modification Process
Response To Other Organism
Positive Regulation Of Post-translational Protein Modification
Non-canonical NF-kappaB Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Defense Response
Defense Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Immune System Process
Immune Response
Positive Regulation Of Lymphocyte Activation
Regulation Of Apoptotic Process
Toll-like Receptor 4 Signaling Pathway
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ubiquitin Protein Ligase Activity
Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein-containing Complex
Protein Binding
CD40 Receptor Binding
Defense Response To Other Organism
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Immune System Process
Regulation Of Programmed Cell Death
Response To External Biotic Stimulus
Innate Immune Response
Positive Regulation Of Protein Ubiquitination
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Signal Transduction
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cell Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Locomotion
Regulation Of Cell Motility
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Intracellular Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Multicellular Organismal Process
Membrane Raft
Regulation Of Cellular Component Organization
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Cellular Response To Oxygen-containing Compound
Regulation Of Programmed Cell Death
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Biological Quality
Kinase Activity
Protein Phosphorylation
Regulation Of Transport
Regulation Of Protein Metabolic Process
Negative Regulation Of Programmed Cell Death
Membrane
Anatomical Structure Morphogenesis
Phosphorylation
Receptor Complex
Regulation Of ERK1 And ERK2 Cascade
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?