CD40 and SLC39A13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD40	SLC39A13
Description		CD40 molecule	solute carrier family 39 member 13
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Zinc Ion Transmembrane Transporter Activity Protein Binding Protein Homodimerization Activity Metal Ion Transmembrane Transporter Activity
	Biological Process	Immune System Process Regulation Of Immunoglobulin Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Bacterium Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Response To Nutrient Levels Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Type II Interferon Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Metal Ion Transport Brown Fat Cell Differentiation Transmembrane Transport Connective Tissue Development Zinc Ion Transmembrane Transport
Pathways
Drugs		Lucatumumab Dacetuzumab
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233 28067908) Kawasaki disease ( 33106546 22446961 22446962) Multiple sclerosis ( 19525955 24076602 22190364 21833088) Rheumatoid arthritis ( 24390342 23143596 30423114 18794853) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood urea nitrogen levels ( 31152163) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163) Diastolic blood pressure ( 27618452 28739976) Estimated glomerular filtration rate ( 31152163 31015462) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hip circumference ( 25673412) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Refractive error ( 32231278) Systolic blood pressure ( 30578418 28739976 27618452) Waist circumference ( 25673412)
Interacting Genes		44 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MIP MS4A1 NCOA6 NSMAF PIK3R1 PLP1 RIPK2 SLC30A2 SLC30A3 SLC39A13 SLC61A1 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	9 interacting genes: CD40 CREB3 F2RL1 MAPK8IP2 OPRM1 PGRMC2 REL SLC16A2 TCF4
Entrez ID		958	91252
HPRD ID		00178	12287
Ensembl ID		ENSG00000101017	ENSG00000165915
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 A0A8Q3SI60 P25942 Q6P2H9	G3V1B2 Q96H72
PDB IDs		1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9 7P3I 8YX1 8YX9
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway CD40 Receptor Complex Tumor Necrosis Factor Receptor Binding Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Response To Stress Regulation Of Immune Response Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Response To Other Organism Positive Regulation Of Post-translational Protein Modification Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Defense Response Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Immune System Process Immune Response Positive Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Toll-like Receptor 4 Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin Protein Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Protein Binding CD40 Receptor Binding Defense Response To Other Organism Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Activation Immune System Process Regulation Of Programmed Cell Death Response To External Biotic Stimulus Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of DNA-binding Transcription Factor Activity	Positive Regulation Of MAPK Cascade Positive Regulation Of Positive Chemotaxis G-protein Alpha-subunit Binding G-protein Beta-subunit Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MAPK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Deacetylase Activity Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Protein Secretion Neuronal Cell Body Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Communication Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Intracellular Signal Transduction Positive Regulation Of Signaling Response To Cobalamin Positive Regulation Of RNA Metabolic Process Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cellular Response To Morphine DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Thyroid-stimulating Hormone Secretion Beta-catenin-TCF7L2 Complex Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Migration Leukocyte Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Erythropoietin Inflammatory Response Cellular Response To Erythropoietin Negative Regulation Of Secretion By Cell
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