CD40 and RIPK2

Number of citations of the paper that reports this interaction (PubMedID 9642260)
0

Data Source:
HPRD (in vivo)

		CD40	RIPK2
Description		CD40 molecule	receptor interacting serine/threonine kinase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Vesicle Protein-containing Complex
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity LIM Domain Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity CARD Domain Binding Caspase Binding Protein Serine Kinase Activity
	Biological Process	Immune System Process Regulation Of Immunoglobulin Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Bacterium Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Response To Nutrient Levels Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Type II Interferon Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway CD4-positive, Alpha-beta T Cell Proliferation P38MAPK Cascade T Cell Proliferation Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Protein Homooligomerization Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Response To Interleukin-12 Response To Interleukin-18 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Xenophagy Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Xenophagy Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways			NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway Downstream TCR signaling p75NTR recruits signalling complexes TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Lucatumumab Dacetuzumab	Fostamatinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233 28067908) Kawasaki disease ( 33106546 22446961 22446962) Multiple sclerosis ( 19525955 24076602 22190364 21833088) Rheumatoid arthritis ( 24390342 23143596 30423114 18794853) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Cerebral amyloid deposition (PET imaging) ( 26252872) Cognitive performance ( 20125193) Crohn's disease ( 23128233) Leprosy ( 20018961 25642632 27976721)
Interacting Genes		44 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MIP MS4A1 NCOA6 NSMAF PIK3R1 PLP1 RIPK2 SLC30A2 SLC30A3 SLC39A13 SLC61A1 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	38 interacting genes: ATG16L1 BCL10 BECN1 BIRC2 CARD16 CARD6 CASP1 CASP8 CD40 CFLAR CHUK IKBKG IRAK1 KDM3A LRRK2 MAVS NGFR NOD1 NOD2 PELI3 PRMT2 SMAD4 SMURF1 TLR2 TLR4 TNFRSF1A TRAF1 TRAF2 TRAF5 TRAF6 UBC UBE2I ULK1 YWHAB YWHAE YWHAG YWHAQ ZNRF4
Entrez ID		958	8767
HPRD ID		00178	04585
Ensembl ID		ENSG00000101017	ENSG00000104312
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 A0A8Q3SI60 P25942 Q6P2H9	A0A0S2Z4Z8 O43353
PDB IDs		1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9 7P3I 8YX1 8YX9	2N7Z 2N83 4C8B 5AR2 5AR3 5AR4 5AR5 5AR7 5AR8 5J79 5J7B 5NG0 5NG2 5NG3 5W5J 5W5O 5YRN 6ES0 6FU5 6GFJ 6GGS 6HMX 6RN8 6RNA 6S1F 6SZE 6SZJ 6UL8 7OBS 7OBT 8AZA 8X2O 9F3V
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway CD40 Receptor Complex Tumor Necrosis Factor Receptor Binding Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Response To Stress Regulation Of Immune Response Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Response To Other Organism Positive Regulation Of Post-translational Protein Modification Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Defense Response Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Immune System Process Immune Response Positive Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Toll-like Receptor 4 Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin Protein Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Protein Binding CD40 Receptor Binding Defense Response To Other Organism Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Activation Immune System Process Regulation Of Programmed Cell Death Response To External Biotic Stimulus Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of DNA-binding Transcription Factor Activity	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Programmed Cell Death Identical Protein Binding Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Immune Response Regulation Of Defense Response Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Intracellular Signal Transduction Activation Of Immune Response Protein-containing Complex Binding Response To External Biotic Stimulus CARD Domain Binding Cellular Response To Oxygen-containing Compound Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cytokine Production Response To Other Organism Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Defense Response Regulation Of Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Response To Stress
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