CD40 and SLC7A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD40	SLC7A1
Description		CD40 molecule	solute carrier family 7 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Protein-containing Complex
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	L-ornithine Transmembrane Transporter Activity Virus Receptor Activity L-histidine Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity L-lysine Transmembrane Transporter Activity Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Immune System Process Regulation Of Immunoglobulin Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Bacterium Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Response To Nutrient Levels Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Type II Interferon Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process	Amino Acid Transport L-amino Acid Transport Lysine Transport Ornithine Transport Positive Regulation Of T Cell Proliferation Symbiont Entry Into Host Cell Transmembrane Transport Amino Acid Import Across Plasma Membrane L-arginine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-ornithine Transmembrane Transport L-lysine Transmembrane Transport L-histidine Import Across Plasma Membrane L-arginine Transmembrane Transport
Pathways			Amino acid transport across the plasma membrane
Drugs		Lucatumumab Dacetuzumab	Lysine Arginine Ornithine
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233 28067908) Kawasaki disease ( 33106546 22446961 22446962) Multiple sclerosis ( 19525955 24076602 22190364 21833088) Rheumatoid arthritis ( 24390342 23143596 30423114 18794853) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Appendicular lean mass ( 33097823) Blood osmolality (transformed sodium) ( 28360221) Diastolic blood pressure ( 27841878) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		44 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MIP MS4A1 NCOA6 NSMAF PIK3R1 PLP1 RIPK2 SLC30A2 SLC30A3 SLC39A13 SLC61A1 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	56 interacting genes: ADGRB3 APOA2 APP AQP6 ATP6V0C C8A CBLIF CCL4 CCL4L2 CD40 CD79A CDIPT CERS4 CMTM2 CREB3L1 EMC6 FAM241B FATE1 FCER1G GALNT15 GET1 GLB1 GPR152 HERPUD2 LEPROT LEPROTL1 LMNA MFF MGST3 MS4A13 NUCB2 ORMDL3 PDCD1LG2 PNLIPRP1 PSCA PTPN9 RNF144A SACM1L SCN3B SEC23A SLC10A6 SLC18A2 SLC30A2 SLC39A2 SLC39A9 SLC52A1 SMCO4 ST6GAL2 STIM1 TMBIM6 TMEM14A TMEM19 TMEM237 TRARG1 TSPO2 YIPF4
Entrez ID		958	6541
HPRD ID		00178	00091
Ensembl ID		ENSG00000101017	ENSG00000139514
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 A0A8Q3SI60 P25942 Q6P2H9	P30825
PDB IDs		1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9 7P3I 8YX1 8YX9
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway CD40 Receptor Complex Tumor Necrosis Factor Receptor Binding Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Response To Stress Regulation Of Immune Response Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Response To Other Organism Positive Regulation Of Post-translational Protein Modification Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Defense Response Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Immune System Process Immune Response Positive Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Toll-like Receptor 4 Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin Protein Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Protein Binding CD40 Receptor Binding Defense Response To Other Organism Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Activation Immune System Process Regulation Of Programmed Cell Death Response To External Biotic Stimulus Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of DNA-binding Transcription Factor Activity	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Serotonin Secretion Zinc Ion Transmembrane Transporter Activity Chemical Homeostasis Zinc Ion Transport Zinc Ion Transmembrane Transport Plasma Membrane Monoatomic Cation Homeostasis Monoatomic Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Organic Hydroxy Compound Transport Monoatomic Ion Homeostasis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Homeostasis Transmembrane Transport Inorganic Ion Transmembrane Transport Negative Regulation Of Growth Hormone Receptor Signaling Pathway Inorganic Ion Homeostasis Monoatomic Ion Transmembrane Transport Serotonin Transport Metal Ion Transport Regulation Of Growth Hormone Receptor Signaling Pathway Acetylcholine Receptor Binding Monoatomic Cation Transmembrane Transport Neuron Remodeling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?