MAP4K4 and SLC9A1

Number of citations of the paper that reports this interaction (PMID 11369779)
24

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MAP4K4	SLC9A1
Gene Name		mitogen-activated protein kinase kinase kinase kinase 4	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cation-transporting ATPase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Solute:proton Antiporter Activity Sodium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein Binding, Bridging Protein Complex Scaffold Calcium-dependent Protein Binding Sodium:proton Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential
	Biological Process	Protein Phosphorylation Signal Transduction By Phosphorylation Microvillus Assembly Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Catalytic Activity	Carbohydrate Metabolic Process Ion Transport Cellular Sodium Ion Homeostasis Regulation Of PH Pathogenesis Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Growth Cell Migration Maintenance Of Cell Polarity Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Focal Adhesion Assembly Regulation Of Sensory Perception Of Pain Cardiac Muscle Cell Differentiation Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Neuron Death Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Sodium Ion Export Cellular Response To Hypoxia Cellular Response To Acidic PH Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Hydrogen Ion Transmembrane Transport Positive Regulation Of Calcium:sodium Antiporter Activity
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism SLC-mediated transmembrane transport Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Sodium/Proton exchangers Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs			Amiloride Homoserine Lactone
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		18 interactors: BRCA1 CASP8 DOK1 GBP3 HIST2H2BE ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	12 interactors: CA2 CHP1 CHP2 DAXX MAP4K4 MAPK1 MAPK14 MDFI TESC TNIK WNK1 YWHAB
Entrez ID		9448	6548
HPRD ID		05235	00123
Ensembl ID		ENSG00000071054	ENSG00000090020
Uniprot IDs		B7Z3V5 O95819	B2RAH2 P19634
PDB IDs			1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2YGG
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Cell Adhesion Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Developmental Process Signaling Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Response To Stimulus Cellular Response To Organic Substance Anatomical Structure Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Death Regulation Of Apoptotic Process System Development Positive Regulation Of Cell Adhesion Regulation Of Cell Death Signal Transduction Response To Abiotic Stimulus Response To Other Organism Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cell Projection Organization Response To Biotic Stimulus Nervous System Development Cellular Response To Mechanical Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Defense Response Response To Organic Substance Axonogenesis Regulation Of Organelle Organization Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Cell Death Axon Development Negative Regulation Of Necrotic Cell Death Response To Stress Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Necroptotic Process Movement Of Cell Or Subcellular Component	Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation MAPK Cascade Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Cellular Localization Cellular Response To Stimulus Regulation Of Protein Transport Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Dephosphorylation Regulation Of Establishment Of Protein Localization Phosphorylation Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transport Positive Regulation Of Signal Transduction Negative Regulation Of Transport Regulation Of JNK Cascade Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Transport Positive Regulation Of Phosphorylation Regulation Of Protein Localization To Nucleus Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport
Tagcloud ?		abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis	atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc4 slc4a7 summarize transporters unifying
Tagcloud (Difference) ?		abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis	atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc4 slc4a7 summarize transporters unifying
Tagcloud (Intersection) ?