MAP4K4 and TBPL2

Number of citations of the paper that reports this interaction (PMID 15234975)
22

Data Source:
BioGRID (two hybrid)

		MAP4K4	TBPL2
Gene Name		mitogen-activated protein kinase kinase kinase kinase 4	TATA box binding protein like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Protein Phosphorylation Signal Transduction By Phosphorylation Microvillus Assembly Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Catalytic Activity	DNA-templated Transcription, Initiation Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		18 interactors: BRCA1 CASP8 DOK1 GBP3 HIST2H2BE ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	4 interactors: DNAJB4 DNAJB5 KPNA2 MAP4K4
Entrez ID		9448	387332
HPRD ID		05235	10607
Ensembl ID		ENSG00000071054
Uniprot IDs		B7Z3V5 O95819	Q6SJ96
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Cell Adhesion Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Developmental Process Signaling Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Response To Stimulus Cellular Response To Organic Substance Anatomical Structure Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Death Regulation Of Apoptotic Process System Development Positive Regulation Of Cell Adhesion Regulation Of Cell Death Signal Transduction Response To Abiotic Stimulus Response To Other Organism Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cell Projection Organization Response To Biotic Stimulus Nervous System Development Cellular Response To Mechanical Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Defense Response Response To Organic Substance Axonogenesis Regulation Of Organelle Organization Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Cell Death Axon Development Negative Regulation Of Necrotic Cell Death Response To Stress Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Necroptotic Process Movement Of Cell Or Subcellular Component	Response To Unfolded Protein Protein Folding Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Tagcloud ?		abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis	bimodular comprises dbd gallus gametogenesis genomics gonads homo intrinsically invertebrates iups melanogaster mus musculus norvegicus rattus rubripes sapiens subphylum tafs takifugu tata tbpl1 troglodytes tropicalis ubiquitously unstructured vertebrates
Tagcloud (Difference) ?		abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis	bimodular comprises dbd gallus gametogenesis genomics gonads homo intrinsically invertebrates iups melanogaster mus musculus norvegicus rattus rubripes sapiens subphylum tafs takifugu tata tbpl1 troglodytes tropicalis ubiquitously unstructured vertebrates
Tagcloud (Intersection) ?