MAP4K4 and RASA1

Number of citations of the paper that reports this interaction (PMID 10669731)
31

Data Source:
HPRD (in vivo)

		MAP4K4	RASA1
Gene Name		mitogen-activated protein kinase kinase kinase kinase 4	RAS p21 protein activator (GTPase activating protein) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Ruffle Cytoplasm Cytosol Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Glycoprotein Binding Ras GTPase Activator Activity Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Protein Phosphorylation Signal Transduction By Phosphorylation Microvillus Assembly Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Catalytic Activity	Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Embryo Development Regulation Of Actin Filament Polymerization Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Signaling by PDGF EPHB-mediated forward signaling Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)	Major depressive disorder ( 23377640) Personality dimensions ( 21173776)
Protein-Protein Interactions		18 interactors: BRCA1 CASP8 DOK1 GBP3 HIST2H2BE ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	73 interactors: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES G3BP1 GNB2L1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		9448	5921
HPRD ID		05235	00745
Ensembl ID		ENSG00000071054	ENSG00000145715
Uniprot IDs		B7Z3V5 O95819	B4DTL2 E9PGC0 P20936 Q59GK3
PDB IDs			1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Regulation Of Cell Adhesion Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Developmental Process Signaling Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Response To Stimulus Cellular Response To Organic Substance Anatomical Structure Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Death Regulation Of Apoptotic Process System Development Positive Regulation Of Cell Adhesion Regulation Of Cell Death Signal Transduction Response To Abiotic Stimulus Response To Other Organism Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cell Projection Organization Response To Biotic Stimulus Nervous System Development Cellular Response To Mechanical Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Defense Response Response To Organic Substance Axonogenesis Regulation Of Organelle Organization Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Cell Death Axon Development Negative Regulation Of Necrotic Cell Death Response To Stress Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Necroptotic Process Movement Of Cell Or Subcellular Component	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Peptidyl-amino Acid Modification Cell Surface Receptor Signaling Pathway Signal Transduction Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Communication Regulation Of Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Immune System Process Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Phosphorylation Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Immune System Process Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound
Tagcloud ?		abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated
Tagcloud (Difference) ?		abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated
Tagcloud (Intersection) ?