MAP4K4 and MOB4

Number of citations of the paper that reports this interaction (PubMedID 32640226)
55

Data Source:
BioGRID (pull down, affinity chromatography technology)

		MAP4K4	MOB4
Description		mitogen-activated protein kinase kinase kinase kinase 4	MOB family member 4, phocein
Image
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion	Cytoplasm Golgi Apparatus Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Creatine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Intracellular Signal Transduction	Negative Regulation Of Hippo Signaling
Pathways		Oxidative Stress Induced Senescence
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)	Allergic rhinitis ( 31361310) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Schizophrenia ( 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		27 interacting genes: BRCA1 CASP8 CTTNBP2NL DOK1 DSCAM GBP3 H2BC21 ITGB1 KIF26B KIF5A LATS1 MAP3K7 MOB4 NCK1 NME7 PPP1CA PPP1CC PPP2CA PRKCE PTK2B RAP2A RASA1 RIPPLY3 SLC9A1 STRIP1 STRN4 TBPL2	32 interacting genes: ARHGEF15 CCDC85B CRMP1 DNM1 EGFR EGLN2 ELK1 EPS15 FADD FBLN1 GDF9 KIDINS220 LATS1 LATS2 LRIF1 MAP4K4 MCM2 MED10 MED31 MYL6 MYO9B NME2 PAICS PLEKHM1 PTPRS RAPGEF2 SCMH1 SETDB1 STK11 STK3 THAP4 UBE2V2
Entrez ID		9448	25843
HPRD ID		05235	10165
Ensembl ID		ENSG00000071054	ENSG00000115540
Uniprot IDs		B7Z3V5 E7EN19 G5E948 O95819 V9HWH3	Q9Y3A3
PDB IDs		4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q 8V5I	5YF4 7K36
Enriched GO Terms of Interacting Partners?		FAR/SIN/STRIPAK Complex Regulation Of Hippo Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Hippo Signaling Regulation Of Supramolecular Fiber Organization Cytoplasm Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Filament Length Regulation Of Cellular Component Size RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Lamellipodium Protein Dephosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Glutamatergic Synapse Protein-macromolecule Adaptor Activity Regulation Of Actin Filament-based Process Postsynapse Positive Regulation Of Locomotion Negative Regulation Of Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Cell Communication Regulation Of Organelle Organization Negative Regulation Of Signaling Dephosphorylation PTW/PP1 Phosphatase Complex Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Signaling Receptor Activator Activity Dendritic Spine Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Synapse Organization Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cellular Component Biogenesis Gamma-tubulin Ring Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Positive Regulation Of Programmed Cell Death	Positive Regulation Of Hippo Signaling Hippo Signaling Regulation Of Growth Regulation Of Hippo Signaling Regulation Of Cell Junction Assembly Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis ATP Binding Nucleotide Binding Negative Regulation Of Growth Regulation Of Macromolecule Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Postsynapse Organization Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Canonical Wnt Signaling Pathway Transcription Regulator Activator Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Synapse Assembly Developmental Process Endocytic Vesicle Clathrin-coated Pit Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Wnt Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription Initiation Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Wnt Signaling Pathway Nerve Growth Factor Signaling Pathway DNA Replication Origin Binding Regulation Of Postsynaptic Density Assembly Positive Regulation Of Cellular Component Biogenesis Protein-containing Complex Assembly Protein Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of DNA-templated Transcription Initiation Protein Serine Kinase Activity Clathrin Coat Assembly Positive Regulation Of Programmed Cell Death Regulation Of Postsynaptic Specialization Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?