GSTM4 and APLP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GSTM4	APLP1
Description		glutathione S-transferase mu 4	amyloid beta precursor like protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Basement Membrane Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Protein Binding Transferase Activity Lyase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding
	Biological Process	Lipid Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process	Regulation Of Translation Endocytosis Apoptotic Process Cell Adhesion Nervous System Development Axonogenesis Central Nervous System Development Animal Organ Morphogenesis Extracellular Matrix Organization Forebrain Development Animal Organ Development Cellular Response To Norepinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cytosolic MRNA Polyadenylation
Pathways		Glutathione conjugation Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Drugs		Glutathione Glutathione sulfonic acid S-octylglutathione Glutathione disulfide gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine Deoxycholic acid 1-Hydroxy-2-S-glutathionyl-3-para-nitrophenoxy-propane S-Hexylglutathione	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alcohol dependence ( 33290381) Seasonality and depression ( 30217971)	Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		10 interacting genes: APLP1 GSTM3 IGSF21 LRIF1 MED31 NELFCD TLE1 TP53 UNC119 ZBTB16	42 interacting genes: ANXA7 APBB1 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24
Entrez ID		2948	333
HPRD ID		00706	00102
Ensembl ID		ENSG00000168765	ENSG00000105290
Uniprot IDs		A0A140VKE3 A6NNT0 Q03013	P51693
PDB IDs		4GTU	3PMR 3Q7G 3Q7L 3QMK 4RD9 4RDA
Enriched GO Terms of Interacting Partners?		Cellular Response To Norepinephrine Stimulus Alpha-2B Adrenergic Receptor Binding Regulation Of Primary Metabolic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Response To Norepinephrine System Development Central Nervous System Development Identical Protein Binding Developmental Process Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Establishment Of Blood-nerve Barrier Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Transcription Repressor Complex Oxidative Stress-induced Premature Senescence Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition PML Body Glucose Catabolic Process To Lactate Via Pyruvate Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Fibroblast Proliferation Germ Cell Nucleus Cellular Response To Actinomycin D Negative Regulation Of Fibroblast Proliferation Regulation Of Transcription Initiation By RNA Polymerase II Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation NELF Complex Regulation Of Macromolecule Metabolic Process Nuclear Matrix Alpha-2A Adrenergic Receptor Binding Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	Regulation Of Cellular Component Organization Inclusion Body Cytoplasm Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Molecular Adaptor Activity Regulation Of Cell Cycle G1/S Phase Transition Nucleus Chromatin Binding Cytosol Protein Sequestering Activity Regulation Of Chaperone-mediated Autophagy Regulation Of Amyloid-beta Formation Negative Regulation Of Growth Cuprous Ion Binding Regulation Of Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Response To Phorbol 13-acetate 12-myristate Regulation Of Cell Population Proliferation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Regulation Of Interleukin-2 Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of SMAD Protein Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Growth Identical Protein Binding Regulation Of Cell Development Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Activation G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Projection Organization Cell Cycle G1/S Phase Transition
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