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GSTM4 and IGSF21
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
GSTM4
IGSF21
Gene Name
glutathione S-transferase mu 4
immunoglobin superfamily, member 21
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Region
Molecular Function
Glutathione Transferase Activity
Enzyme Binding
Protein Homodimerization Activity
Glutathione Binding
Biological Process
Glutathione Metabolic Process
Xenobiotic Metabolic Process
Nitrobenzene Metabolic Process
Xenobiotic Catabolic Process
Small Molecule Metabolic Process
Glutathione Derivative Biosynthetic Process
Pathways
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Defective UGT1A4 causes hyperbilirubinemia
Glutathione conjugation
Metabolic disorders of biological oxidation enzymes
Phase II conjugation
Defective UGT1A1 causes hyperbilirubinemia
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Biological oxidations
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Defective GGT1 causes Glutathionuria (GLUTH)
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Glutathione
Glutathione Sulfonic Acid
S-Octylglutathione
Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine
1-Hydroxy-2-S-Glutathionyl-3-Para-Nitrophenoxy-Propane
S-Hexylglutathione
Diseases
GWAS
Diabetic retinopathy (
21441570
)
Erectile dysfunction and prostate cancer treatment (
20932654
)
Protein-Protein Interactions
10 interactors:
APLP1
GSTM3
IGSF21
LRIF1
MED31
NELFCD
TLE1
TP53
UNC119
ZBTB16
32 interactors:
ALDH2
ANXA3
ATF3
BCR
BTBD2
CRCT1
DGKD
EPB41L3
ERH
ETHE1
GADD45A
GIPC2
GSK3B
GSTM4
HSPB1
KRAS
MAD2L1BP
NACA
NREP
PAEP
PAFAH1B3
PCDHA4
PRMT1
PSMD11
RPP14
S100A8
SEPHS1
SERPINB9
SULT1E1
TMSB4X
TRBV2
UBE2V2
Entrez ID
2948
84966
HPRD ID
00706
11309
Ensembl ID
ENSG00000168765
ENSG00000117154
Uniprot IDs
Q03013
Q96ID5
PDB IDs
4GTU
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Fibroblast Proliferation
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Clathrin-mediated Endocytosis
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Fibroblast Proliferation
Regulation Of Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Macromitophagy
Negative Regulation Of Caveolin-mediated Endocytosis
Oligodendrocyte Apoptotic Process
Negative Regulation Of Gene Expression
Cellular Detoxification Of Nitrogen Compound
Cytokinesis, Completion Of Separation
Negative Regulation Of Helicase Activity
Cellular Response To Norepinephrine Stimulus
Notch Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Nitrobenzene Metabolic Process
Negative Regulation Of Cell Proliferation
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Protein Localization To Nucleus
Positive Regulation Of NK T Cell Differentiation
Detoxification Of Nitrogen Compound
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Response To Toxic Substance
Regulation Of RNA Metabolic Process
Positive Regulation Of Thymocyte Apoptotic Process
Response To Norepinephrine
Positive Regulation Of Cell Aging
Establishment Of Blood-nerve Barrier
Male Germ-line Stem Cell Asymmetric Division
Response To Wounding
Regulation Of Apoptotic Process
Regulation Of Cell Death
Wound Healing
Positive Regulation Of Protein Metabolic Process
Response To Stress
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Negative Regulation Of Catalytic Activity
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Transferase Activity
Response To Stimulus
Developmental Process
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Response To Xenobiotic Stimulus
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Apoptotic Process
Epidermal Growth Factor Receptor Signaling Pathway
Nervous System Development
ERBB Signaling Pathway
Regulation Of Proteolysis
Programmed Cell Death
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Death
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Death
Cellular Response To Stimulus
Blood Coagulation
Platelet Activation
Hemostasis
Regulation Of Protein Kinase Activity
Response To Biotic Stimulus
Multicellular Organismal Development
Positive Regulation Of Catalytic Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Rac GTPase Activity
Positive Regulation Of Endothelial Cell Migration
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Kinase Activity
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Growth
Tagcloud
?
abundances
agt
ahr
amongst
aryl
came
car3
coherency
constitutive
contrasting
creg1
ctsc
e2f6
enpp1
gatm
halogenated
hydrocarbon
hydrocarbons
inferences
kcnj8
me1
overlap
pdk1
physiologic
profiled
slc35a3
sqrdl
transcriptomic
xenobiotic
Tagcloud (Difference)
?
abundances
agt
ahr
amongst
aryl
came
car3
coherency
constitutive
contrasting
creg1
ctsc
e2f6
enpp1
gatm
halogenated
hydrocarbon
hydrocarbons
inferences
kcnj8
me1
overlap
pdk1
physiologic
profiled
slc35a3
sqrdl
transcriptomic
xenobiotic
Tagcloud (Intersection)
?