Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
GSTM4 and MED31
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
GSTM4
MED31
Gene Name
glutathione S-transferase mu 4
mediator complex subunit 31
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Nucleoplasm
Mediator Complex
Molecular Function
Glutathione Transferase Activity
Enzyme Binding
Protein Homodimerization Activity
Glutathione Binding
RNA Polymerase II Transcription Cofactor Activity
Protein Binding
Protein Complex Binding
Biological Process
Glutathione Metabolic Process
Xenobiotic Metabolic Process
Nitrobenzene Metabolic Process
Xenobiotic Catabolic Process
Small Molecule Metabolic Process
Glutathione Derivative Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Protein Complex Assembly
Gene Expression
Negative Regulation Of Fibroblast Proliferation
Limb Development
Pathways
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Defective UGT1A4 causes hyperbilirubinemia
Glutathione conjugation
Metabolic disorders of biological oxidation enzymes
Phase II conjugation
Defective UGT1A1 causes hyperbilirubinemia
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Biological oxidations
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Defective GGT1 causes Glutathionuria (GLUTH)
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Glutathione
Glutathione Sulfonic Acid
S-Octylglutathione
Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine
1-Hydroxy-2-S-Glutathionyl-3-Para-Nitrophenoxy-Propane
S-Hexylglutathione
Diseases
GWAS
Protein-Protein Interactions
10 interactors:
APLP1
GSTM3
IGSF21
LRIF1
MED31
NELFCD
TLE1
TP53
UNC119
ZBTB16
58 interactors:
AES
AGR2
ANXA7
ASCC2
C2orf44
CACNB4
CCT7
CDKN1A
CPE
DAZAP2
DLEU1
DNM1
EEF1G
EGR2
EPN1
ERH
FAM118B
GADD45G
GSTM4
HGH1
HMOX2
HNRNPUL1
HSPB1
HSPB3
HTT
LAMA4
LYPLA2
MAFG
MED18
MED19
MED7
MED8
MED9
MOB4
NFATC2
NR4A1
ORAI2
PABPC4
PAFAH1B3
PFDN1
PMF1
PQBP1
PRMT1
PSMD11
RAB25
RBM23
RFC5
RPA2
SAT1
SELENBP1
SERPINB9
SMN1
TGIF1
TINAGL1
TK1
UBE2B
ZBTB45
ZSCAN1
Entrez ID
2948
51003
HPRD ID
00706
14382
Ensembl ID
ENSG00000168765
ENSG00000108590
Uniprot IDs
Q03013
Q9Y3C7
PDB IDs
4GTU
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Fibroblast Proliferation
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Clathrin-mediated Endocytosis
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Fibroblast Proliferation
Regulation Of Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Macromitophagy
Negative Regulation Of Caveolin-mediated Endocytosis
Oligodendrocyte Apoptotic Process
Negative Regulation Of Gene Expression
Cellular Detoxification Of Nitrogen Compound
Cytokinesis, Completion Of Separation
Negative Regulation Of Helicase Activity
Cellular Response To Norepinephrine Stimulus
Notch Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Nitrobenzene Metabolic Process
Negative Regulation Of Cell Proliferation
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Protein Localization To Nucleus
Positive Regulation Of NK T Cell Differentiation
Detoxification Of Nitrogen Compound
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Response To Toxic Substance
Regulation Of RNA Metabolic Process
Positive Regulation Of Thymocyte Apoptotic Process
Response To Norepinephrine
Positive Regulation Of Cell Aging
Establishment Of Blood-nerve Barrier
Male Germ-line Stem Cell Asymmetric Division
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Gene Expression
Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription, DNA-templated
RNA Metabolic Process
RNA Biosynthetic Process
Developmental Process
Biosynthetic Process
Regulation Of Gene Expression
Anatomical Structure Development
Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Differentiation
Multicellular Organismal Development
Response To Stimulus
Neurotransmitter Uptake
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleotide-excision Repair, DNA Gap Filling
Negative Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Programmed Cell Death
Telomere Maintenance Via Semi-conservative Replication
System Development
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Cell Death
Telomere Maintenance Via Recombination
Nuclear DNA Replication
Mitotic DNA Damage Checkpoint
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Integrity Checkpoint
Embryo Development Ending In Birth Or Egg Hatching
DNA-templated Transcription, Initiation
Response To External Stimulus
Regulation Of Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
abundances
agt
ahr
amongst
aryl
came
car3
coherency
constitutive
contrasting
creg1
ctsc
e2f6
enpp1
gatm
halogenated
hydrocarbon
hydrocarbons
inferences
kcnj8
me1
overlap
pdk1
physiologic
profiled
slc35a3
sqrdl
transcriptomic
xenobiotic
Tagcloud (Difference)
?
abundances
agt
ahr
amongst
aryl
came
car3
coherency
constitutive
contrasting
creg1
ctsc
e2f6
enpp1
gatm
halogenated
hydrocarbon
hydrocarbons
inferences
kcnj8
me1
overlap
pdk1
physiologic
profiled
slc35a3
sqrdl
transcriptomic
xenobiotic
Tagcloud (Intersection)
?