GSTM4 and UNC119

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GSTM4	UNC119
Gene Name		glutathione S-transferase mu 4	unc-119 homolog (C. elegans)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone
	Molecular Function	Glutathione Transferase Activity Enzyme Binding Protein Homodimerization Activity Glutathione Binding	Protein Binding Lipid Binding
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione Glutathione Sulfonic Acid S-Octylglutathione Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine 1-Hydroxy-2-S-Glutathionyl-3-Para-Nitrophenoxy-Propane S-Hexylglutathione
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APLP1 GSTM3 IGSF21 LRIF1 MED31 NELFCD TLE1 TP53 UNC119 ZBTB16	92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24
Entrez ID		2948	9094
HPRD ID		00706	04927
Ensembl ID		ENSG00000168765	ENSG00000109103
Uniprot IDs		Q03013	Q13432
PDB IDs		4GTU	3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Fibroblast Proliferation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Fibroblast Proliferation Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Macromitophagy Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Negative Regulation Of Gene Expression Cellular Detoxification Of Nitrogen Compound Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Response To Norepinephrine Stimulus Notch Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Nitrobenzene Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Positive Regulation Of NK T Cell Differentiation Detoxification Of Nitrogen Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Toxic Substance Regulation Of RNA Metabolic Process Positive Regulation Of Thymocyte Apoptotic Process Response To Norepinephrine Positive Regulation Of Cell Aging Establishment Of Blood-nerve Barrier Male Germ-line Stem Cell Asymmetric Division	T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
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