GSTM4 and GSTM3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GSTM4	GSTM3
Gene Name		glutathione S-transferase mu 4	glutathione S-transferase mu 3 (brain)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Sperm Fibrous Sheath Extracellular Vesicular Exosome
	Molecular Function	Glutathione Transferase Activity Enzyme Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Establishment Of Blood-nerve Barrier Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Response To Estrogen Small Molecule Metabolic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione Glutathione Sulfonic Acid S-Octylglutathione Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine 1-Hydroxy-2-S-Glutathionyl-3-Para-Nitrophenoxy-Propane S-Hexylglutathione	Glutathione
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APLP1 GSTM3 IGSF21 LRIF1 MED31 NELFCD TLE1 TP53 UNC119 ZBTB16	6 interactors: GSTM1 GSTM2 GSTM4 GSTM5 SH3GL2 UCHL5
Entrez ID		2948	2947
HPRD ID		00706	00712
Ensembl ID		ENSG00000168765	ENSG00000134202
Uniprot IDs		Q03013	P21266 Q6FGJ9
PDB IDs		4GTU	3GTU
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Fibroblast Proliferation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Fibroblast Proliferation Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Macromitophagy Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Negative Regulation Of Gene Expression Cellular Detoxification Of Nitrogen Compound Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Response To Norepinephrine Stimulus Notch Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Nitrobenzene Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Positive Regulation Of NK T Cell Differentiation Detoxification Of Nitrogen Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Toxic Substance Regulation Of RNA Metabolic Process Positive Regulation Of Thymocyte Apoptotic Process Response To Norepinephrine Positive Regulation Of Cell Aging Establishment Of Blood-nerve Barrier Male Germ-line Stem Cell Asymmetric Division	Glutathione Derivative Biosynthetic Process Nitrobenzene Metabolic Process Glutathione Metabolic Process Xenobiotic Catabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Cellular Detoxification Of Nitrogen Compound Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Detoxification Of Nitrogen Compound Sulfur Compound Metabolic Process Catabolic Process Cellular Response To Stimulus Response To Toxic Substance Small Molecule Metabolic Process Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Response To Stimulus Biosynthetic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Skeletal Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Nitrogen Compound Metabolic Process Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Stress Negative Regulation Of Cation Channel Activity Forebrain Morphogenesis Relaxation Of Muscle Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Lateral Ventricle Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Receptor Internalization Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Positive Regulation Of Cation Channel Activity Response To Growth Factor Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Brain Morphogenesis
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	5r acquire bax clonogenic exact facilitation fractionated hcc hepatoma immunoblotting irradiation lymphocytic modality p27 parental pivotal plc prf radiation radioresistance radioresistant radiosensitivity radiotherapy reversing rt sensitized sensitizing transferase
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	5r acquire bax clonogenic exact facilitation fractionated hcc hepatoma immunoblotting irradiation lymphocytic modality p27 parental pivotal plc prf radiation radioresistance radioresistant radiosensitivity radiotherapy reversing rt sensitized sensitizing transferase
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