HIP1R and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 11889126)
0

Data Source:
HPRD (in vitro)

		HIP1R	ACTA1
Description		huntingtin interacting protein 1 related	actin alpha 1, skeletal muscle
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Endomembrane System Postsynaptic Density Membrane Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm Synaptic Membrane Postsynapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Digestive System Development Regulation Of Gastric Acid Secretion Membrane Organization Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Postsynapse Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS		A body shape index ( 34021172) Atrial fibrillation ( 29892015 30061737) Body mass index ( 29273807) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ACTA1 ACTB CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT TFIP11 TRIM27 UBC	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		9026	58
HPRD ID		10412	00030
Ensembl ID		ENSG00000130787	ENSG00000143632
Uniprot IDs		B3KQW8 B4DPL0 O75146	P68133
PDB IDs		1R0D	7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Cytosol Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Pit Clathrin Coat Of Coated Pit Clathrin Vesicle Coat Vesicle-mediated Transport Presynaptic Endocytic Zone Membrane Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytoplasm Endocytosis Clathrin-dependent Endocytosis Intracellular Transport Nitric-oxide Synthase Regulator Activity Receptor-mediated Endocytosis Import Into Cell Cytoplasmic Vesicle Membrane Clathrin Complex Clathrin Light Chain Binding Postsynaptic Actin Cytoskeleton Clathrin Heavy Chain Binding Profilin Binding Cytoskeleton Regulation Of Cellular Component Organization Clathrin-coated Vesicle Cellular Localization Establishment Of Localization In Cell Actin Filament Regulation Of Organelle Organization Neuron Projection Morphogenesis Structural Constituent Of Cytoskeleton Cell Projection Morphogenesis Endolysosome Membrane Intracellular Protein Transport Developmental Process Cortical Cytoskeleton Peptide Binding Plasma Membrane Bounded Cell Projection Assembly Face Morphogenesis Cell Projection Assembly Axonogenesis Protein Transport Dynein Intermediate Chain Binding Clathrin Binding Cell Projection Organization Lamellipodium Anatomical Structure Homeostasis Tissue Homeostasis Substantia Nigra Development	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
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