HIP1R and DYNLL1

Number of citations of the paper that reports this interaction (PubMedID 14760703)
0

Data Source:
HPRD (in vitro)

		HIP1R	DYNLL1
Description		huntingtin interacting protein 1 related	dynein light chain LC8-type 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Endomembrane System Postsynaptic Density Membrane Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm Synaptic Membrane Postsynapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Kinetochore Nucleus Chromosome Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium COP9 Signalosome Microtubule Cytoskeleton Membrane Secretory Granule Dynein Complex Site Of Double-strand Break Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm
	Molecular Function	Actin Binding Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Deoxyribonuclease Inhibitor Activity Scaffold Protein Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Digestive System Development Regulation Of Gastric Acid Secretion Membrane Organization Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Postsynapse Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Apoptotic Process DNA Damage Response Microtubule-based Process Spermatid Development Substantia Nigra Development Positive Regulation Of Intracellular Transport Intraciliary Retrograde Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Atrial fibrillation ( 29892015 30061737) Body mass index ( 29273807) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		13 interacting genes: ACTA1 ACTB CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT TFIP11 TRIM27 UBC	108 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BACH1 BCAS1 BCL2L11 BMF C14orf119 C19orf44 CA2 CACNB1 CCDC28A CIMAP1A CLIP2 COXFA4L2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 DYRK1A EEF1A1 ERG28 FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORC3 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 REDIC1 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710
Entrez ID		9026	8655
HPRD ID		10412	03334
Ensembl ID		ENSG00000130787	ENSG00000088986
Uniprot IDs		B3KQW8 B4DPL0 O75146	P63167 Q6FGH9
PDB IDs		1R0D	1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2 7D35 8PR0 8PR1 8PTK 8RGG
Enriched GO Terms of Interacting Partners?		Cytosol Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Pit Clathrin Coat Of Coated Pit Clathrin Vesicle Coat Vesicle-mediated Transport Presynaptic Endocytic Zone Membrane Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytoplasm Endocytosis Clathrin-dependent Endocytosis Intracellular Transport Nitric-oxide Synthase Regulator Activity Receptor-mediated Endocytosis Import Into Cell Cytoplasmic Vesicle Membrane Clathrin Complex Clathrin Light Chain Binding Postsynaptic Actin Cytoskeleton Clathrin Heavy Chain Binding Profilin Binding Cytoskeleton Regulation Of Cellular Component Organization Clathrin-coated Vesicle Cellular Localization Establishment Of Localization In Cell Actin Filament Regulation Of Organelle Organization Neuron Projection Morphogenesis Structural Constituent Of Cytoskeleton Cell Projection Morphogenesis Endolysosome Membrane Intracellular Protein Transport Developmental Process Cortical Cytoskeleton Peptide Binding Plasma Membrane Bounded Cell Projection Assembly Face Morphogenesis Cell Projection Assembly Axonogenesis Protein Transport Dynein Intermediate Chain Binding Clathrin Binding Cell Projection Organization Lamellipodium Anatomical Structure Homeostasis Tissue Homeostasis Substantia Nigra Development	Cytoskeleton Microtubule Cytoplasm Postsynaptic Density Microtubule Binding Neurotrophin Receptor Activity Neurotrophin Binding Cytosol Pyruvate Metabolic Process Neuron Projection Morphogenesis Nucleotide Binding Cell Projection Morphogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Cytoskeleton Organization Actin Filament Identical Protein Binding ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Microtubule-based Process Apical Junction Complex ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Cellular Component Biogenesis Replication Fork CAMP-dependent Protein Kinase Inhibitor Activity Cytoskeleton-dependent Intracellular Transport Dendritic Spine Organelle Organization Axon Establishment Of Organelle Localization Axonogenesis Microtubule Associated Complex Carbohydrate Catabolic Process Peptidyl-cysteine S-nitrosylase Activity 6-phosphofructokinase Activity 6-phosphofructokinase Complex Beta-tubulin Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Microtubule Cytoskeleton Organization Substantia Nigra Development Negative Regulation Of Protein Import Into Nucleus Myelination In Peripheral Nervous System Regulation Of Transport Nucleoside Diphosphate Metabolic Process Regulation Of Transepithelial Transport Calyx Of Held Fructose-6-phosphate Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?