ACADVL and SOCS3

Number of citations of the paper that reports this interaction (PubMedID 22093833)
0

Data Source:
BioGRID (pull down)

		ACADVL	SOCS3
Description		acyl-CoA dehydrogenase very long chain	suppressor of cytokine signaling 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Membrane Mitochondrial Nucleoid	Cytosol Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Fatty-acyl-CoA Binding Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding
	Biological Process	Temperature Homeostasis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Catabolic Process Response To Cold Energy Derivation By Oxidation Of Organic Compounds Epithelial Cell Differentiation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor
Pathways		XBP1(S) activates chaperone genes Beta oxidation of palmitoyl-CoA to myristoyl-CoA	Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Age-related hearing impairment ( 34108613) Metabolite levels ( 23823483)	Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)
Interacting Genes		5 interacting genes: GPHN LINC01554 RPSA SOCS3 TAF1B	66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ
Entrez ID		37	9021
HPRD ID		01940	05006
Ensembl ID		ENSG00000072778	ENSG00000184557
Uniprot IDs		B3KPA6 P49748	O14543 Q6FI39
PDB IDs		2UXW 3B96 7S7G
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Core Factor Complex Glycine Receptor Clustering Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity Laminin Receptor Activity RNA Polymerase Transcription Factor SL1 Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I Transcription Regulator Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Specialization, Intracellular Component Molybdopterin Cofactor Binding Nitrate Reductase Activity Molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Gamma-aminobutyric Acid Receptor Clustering Cellular Response To Interleukin-17 Protein Tyrosine Kinase Inhibitor Activity Glycinergic Synapse RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Branching Involved In Labyrinthine Layer Morphogenesis Postsynaptic Specialization T-helper 17 Cell Lineage Commitment Neurotransmitter-gated Ion Channel Clustering Ribosomal Small Subunit Assembly Inhibitory Synapse Transcription By RNA Polymerase I Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Laminin Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Lineage Commitment Small Ribosomal Subunit TBP-class Protein Binding RRNA Transcription CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Cytokine Receptor Binding Negative Regulation Of Receptor Signaling Pathway Via STAT Placenta Blood Vessel Development T Cell Lineage Commitment Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Synaptic Transmission, GABAergic	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation
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