CSF1R

Gene Name		colony stimulating factor 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Macrophage Colony-stimulating Factor Receptor Activity ATP Binding Protein Phosphatase Binding Cytokine Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Phosphatidylinositol Metabolic Process Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Chemokine Secretion Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs		Imatinib Sunitinib 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
Diseases
GWAS
Protein-protein Interactions		18 interactors: CBL CSF1 FYN GRAP2 GRB2 INPP5D INPPL1 LYN PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1
Entrez ID		1436
HPRD ID		01269
Ensembl ID		ENSG00000182578
Uniprot IDs		P07333
PDB IDs		2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7
Enriched GO Terms of Interacting Partners?		Response To Peptide Hormone Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Innate Immune Response Leukocyte Migration Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Fc-epsilon Receptor Signaling Pathway Response To Hormone Blood Coagulation Hemostasis Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signaling Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Response To Wounding Antigen Receptor-mediated Signaling Pathway Response To Insulin Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Migration Cellular Response To Growth Factor Stimulus Locomotion Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Motility Positive Regulation Of Immune System Process
Tagcloud ?		abl1 abl2 adding amenable charities crizotinib crlf2 dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined