CSF1R and SOCS1

Number of citations of the paper that reports this interaction (PubMedID 10022833)
84

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CSF1R	SOCS1
Description		colony stimulating factor 1 receptor	suppressor of cytokine signaling 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell Surface Membrane Receptor Complex CSF1-CSF1R Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Phosphatase Binding Cytokine Binding Protein Homodimerization Activity	Protein Kinase Inhibitor Activity Cytokine Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune System Process Myeloid Leukocyte Differentiation Response To Ischemia Response To Stress Inflammatory Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Anatomical Structure Morphogenesis Positive Regulation Of Macrophage Chemotaxis Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Olfactory Bulb Development Forebrain Neuron Differentiation Regulation Of Cell Morphogenesis Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Positive Regulation Of Chemokine Production Regulation Of Actin Cytoskeleton Organization Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Host-mediated Activation Of Viral Process Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Protein Autophosphorylation Animal Organ Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Microglial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Macrophage Proliferation Regulation Of Macrophage Migration Positive Regulation Of Cell Motility	Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Macrophage Differentiation Developmental Process Intracellular Signal Transduction Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Fat Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus
Pathways		Other interleukin signaling Transcriptional Regulation by VENTX Signaling by CSF1 (M-CSF) in myeloid cells	Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Imatinib Sunitinib Linifanib 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib
Diseases		Choriocarcinoma
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin levels ( 33491795) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494)	Allergy ( 27182965) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 29273806) Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease ( 28067908) Crohn's disease and psoriasis ( 22482804) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 27399966 26502338)
Interacting Genes		23 interacting genes: CBL CSF1 CTDSP1 CTDSP2 FYN GRAP2 GRB2 INPP5D INPPL1 KIT LAMC2 LYN PIK3CA PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1	54 interacting genes: AXL BLK COMMD1 CRK CSF1 CSF1R CUEDC2 CXCR4 CYTIP EGFR ELOB ELOC ERBB2 ERBB4 FLT3 FYN GHR GRB2 IFNAR1 IFNGR1 IGF1R IL2RB INSR IRF7 IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT LCK LYN MET MIR924HG MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 PTK2 RELA SH3GL1 SRC TEC TEK TIRAP TP53 TRIM8 TYK2 VAV1 VAV2 YES1
Entrez ID		1436	8651
HPRD ID		01269	04669
Ensembl ID		ENSG00000182578	ENSG00000185338
Uniprot IDs		P07333	O15524 Q4JHT5
PDB IDs		2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM 6IG8 6N33 6T2W 6WXJ 7MFC 8CGC 8JOT 8W1L
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction SH3 Domain Binding Fc Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Immune System Process Immune Effector Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Myeloid Leukocyte Differentiation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Activation Signal Transduction Immune System Process Mononuclear Cell Differentiation Regulation Of Immune Response Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway T Cell Costimulation Leukocyte Activation Leukocyte Differentiation Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway Insulin Receptor Substrate Binding Myeloid Cell Differentiation Activation Of Immune Response Regulation Of Actin Filament Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin-like Growth Factor Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Defense Response Lymphocyte Activation T Cell Activation Response To Insulin Regulation Of Developmental Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune System Process Protein Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Phosphorylation Regulation Of Signal Transduction Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process Protein Phosphatase Binding Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of MAPK Cascade Protein Autophosphorylation Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Growth Hormone Receptor Signaling Pathway Immune Response-regulating Signaling Pathway ATP Binding Immune Response-activating Signaling Pathway Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Regulation Of Immune Response Plasma Membrane Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility
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