SYNJ2 and ITSN2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SYNJ2	ITSN2
Gene Name		synaptojanin 2	intersectin 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity
Pathways		Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Cannabis use (initiation) ( 22823124)	Working memory ( 21107309)
Protein-Protein Interactions		7 interactors: GRB2 ITSN1 ITSN2 NCK1 RAC1 SH3GL2 SYNJ2BP	75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		8871	50618
HPRD ID		10259	09193
Ensembl ID		ENSG00000078269	ENSG00000198399
Uniprot IDs		B4DG94 O15056	A6H8W8 Q9NZM3
PDB IDs		1UFW	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Endocytosis Axon Guidance Axonogenesis Positive Regulation Of Signal Transduction Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Regulation Of Signal Transduction Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Signaling Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of Actin Filament Polymerization Cell Morphogenesis Positive Regulation Of Protein Polymerization Neuron Differentiation Cell Projection Organization Locomotion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Complex Assembly Response To Growth Factor Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Movement Of Cell Or Subcellular Component Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Generation Of Neurons Positive Regulation Of Homotypic Cell-cell Adhesion Neurogenesis Regulation Of Receptor Internalization Positive Regulation Of Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Phagocytosis Synaptic Vesicle Endocytosis Cell Development Fc Receptor Signaling Pathway Response To External Stimulus	Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj1 targetable xenografts	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Difference) ?		aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj1 targetable xenografts	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Intersection) ?