SYNJ2

Description		synaptojanin 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Cell Projection Membrane Raft Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Membrane Organization
Pathways		Synthesis of PIPs at the plasma membrane Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Age-related hearing impairment ( 34108613) Cannabis use (initiation) ( 22823124) Gamma glutamyl transferase levels ( 29403010 33339817) Intraocular pressure ( 29617998) Lipoprotein (a) levels ( 26377243) Platelet distribution width ( 32888494)
Novel Interacting Genes		2 novel interacting genes: ATXN7 DYNLT1
Interacting Genes		6 interacting genes: GRB2 ITSN1 ITSN2 NCK1 RAC1 SYNJ2BP
Entrez ID		8871
HPRD ID		10259
Ensembl ID		ENSG00000078269
Uniprot IDs		A0A1W2PR85 B4DG94 O15056
PDB IDs		1UFW
Enriched GO Terms of Interacting Partners?		Clathrin-dependent Synaptic Vesicle Endocytosis Protein-macromolecule Adaptor Activity Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Endocytosis Regulation Of Actin Filament Length Presynaptic Membrane Intracellular Vesicle Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Receptor-mediated Endocytosis Positive Regulation Of Cytoskeleton Organization Ephrin Receptor Binding Positive Regulation Of Protein-containing Complex Assembly Clathrin-dependent Endocytosis Import Into Cell Regulation Of MAPK Cascade Vesicle Membrane Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Endocytosis Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Lamellipodium Organization Presynaptic Endocytosis Regulation Of Dendritic Spine Development Regulation Of Endocytosis Regulation Of Actin Cytoskeleton Organization Guanyl-nucleotide Exchange Factor Adaptor Activity Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Grb2-EGFR Complex Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Vesicle-mediated Transport In Synapse
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