ACTN3 and NRAP

Number of citations of the paper that reports this interaction (PubMedID 12692149)
0

Data Source:
HPRD (two hybrid, in vitro)

		ACTN3	NRAP
Description		actinin alpha 3	nebulin related anchoring protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome	Cytoplasm Fascia Adherens Muscle Tendon Junction Myofibril Z Disc
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Actin Binding Protein Binding Vinculin Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	Cardiac Muscle Thin Filament Assembly
Pathways		Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)	Heel bone mineral density ( 30598549) Plasma factor VII activating protease levels ( 30070759) QT interval ( 29874175)
Interacting Genes		61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426	8 interacting genes: ACTA1 ACTB ACTN3 KLHL41 PRKAA2 TLN1 TRIM63 VCL
Entrez ID		89	4892
HPRD ID		02148	04189
Ensembl ID		ENSG00000248746	ENSG00000197893
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	A0A0A0MRM2 Q86VF7
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding	Muscle System Process Actin Cytoskeleton Brush Border Cell Junction Assembly Platelet Aggregation Homotypic Cell-cell Adhesion Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Actin Filament Muscle Atrophy Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Filament-based Process Cell-cell Junction Assembly Adherens Junction Assembly Focal Adhesion Regulation Of Generation Of Precursor Metabolites And Energy Pseudopodium Cell Junction Organization Negative Regulation Of Glycolytic Process Negative Regulation Of ATP Metabolic Process M Band Cell-cell Junction Organization Adherens Junction Muscle Contraction Maintenance Of Blood-brain Barrier Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoskeleton Adherens Junction Organization Sarcomere Regulation Of Small Molecule Metabolic Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Focal Adhesion Assembly Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Regulation Of Myoblast Differentiation Actin Binding Regulation Of Cell-substrate Junction Organization Cytoskeleton Organization Cytoplasm Muscle Cell Development
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