ACTN3

Gene Name		actinin, alpha 3 (gene/pseudogene)
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Gene Ontology Annotations	Cellular Component	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Protein Homodimerization Activity
	Biological Process	Muscle Filament Sliding Regulation Of Apoptotic Process Focal Adhesion Assembly
Pathways		Striated Muscle Contraction Nephrin interactions
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-protein Interactions		17 interactors: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2
Entrez ID		89
HPRD ID		02148
Ensembl ID		ENSG00000248746
Uniprot IDs		B4DZQ2 Q08043 Q4VAM3
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Regulation Of Cell Death Cellular Component Assembly Protein Localization To Cell Junction Platelet Degranulation Regulation Of Apoptotic Process Actin Filament-based Process Actin Crosslink Formation Blood Coagulation Hemostasis Protein Polyubiquitination Focal Adhesion Assembly Platelet Activation Apoptotic Process Cell Junction Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway NIK/NF-kappaB Signaling Cell-cell Junction Organization Programmed Cell Death Protein Autoubiquitination Cell Death Death Regulation Of Body Fluid Levels Tight Junction Assembly Adherens Junction Assembly Actin Cytoskeleton Organization Wound Healing Cytoskeleton Organization Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Protein Homooligomerization Positive Regulation Of Transporter Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Cardiac Muscle Thin Filament Assembly Actin Filament Bundle Assembly Response To Wounding Regulation Of Signal Transduction Actin Filament Organization Apical Junction Assembly Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Ion Transmembrane Transport Myofibril Assembly Exocytosis Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cytokine Production Adherens Junction Organization Regulation Of Signaling Cellular Response To Tumor Necrosis Factor
Tagcloud ?		ace bdkrb2 chi2 cl cmj competition counter discriminate distributions elite explosive forward genotypic italian italians jump leg look players sedentary sj soccer squat stepwise strength top traits variance