ACTN3 and CIMAP1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACTN3	CIMAP1B
Description		actinin alpha 3	ciliary microtubule associated protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome	Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Protein Binding
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426	8 interacting genes: ACTN2 ACTN3 FHL3 HSF2BP KRTAP3-3 MDFI MKRN3 SPTA1
Entrez ID		89	440836
HPRD ID		02148	18640
Ensembl ID		ENSG00000248746	ENSG00000177989
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	A0A8C8KQ56 A1L1A8 A8MYP8 B5MC17 B5MD02
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding	Cortical Actin Cytoskeleton Actin Filament-based Process Actin Binding Actin Cytoskeleton Organization Z Disc Pseudopodium Focal Adhesion Assembly Actin Filament Binding Cell Junction Cell-substrate Junction Assembly Cell-substrate Junction Organization Structural Constituent Of Muscle Regulation Of Actin Filament Depolymerization Actin Cytoskeleton Sarcomere Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Titin Z Domain Binding Muscle Cell Development Cytoskeleton Organization Focal Adhesion Actin Filament Regulation Of Protein Depolymerization Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Interleukin-2 Receptor Complex Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Regulation Of Protein-containing Complex Disassembly Microspike Assembly Transmembrane Transporter Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Integrin Binding FATZ Binding Positive Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity Calcium Ion Binding LIM Domain Binding Negative Regulation Of Relaxation Of Muscle Response To Denervation Involved In Regulation Of Muscle Adaptation Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Adaptation Striated Muscle Atrophy
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