ACTN3 and DUX4L9

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (two hybrid)

		ACTN3	DUX4L9
Description		actinin alpha 3	double homeobox 4 like 9 (pseudogene)
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426	10 interacting genes: ACTA1 ACTN3 FHL3 MSS51 MYH2 NDUFB10 RBM24 RPL4 SF1 VDAC2
Entrez ID		89	100288711
HPRD ID		02148
Ensembl ID		ENSG00000248746	ENSG00000224807
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding	Sarcomere Actin Filament Muscle System Process Stress Fiber Regulation Of Myotube Differentiation Actin Binding Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Muscle Cell Differentiation Muscle Cell Development Actin Filament-based Process Positive Regulation Of Bone Mineralization Involved In Bone Maturation Focal Adhesion Positive Regulation Of Skeletal Muscle Fiber Differentiation Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Negative Regulation Of Relaxation Of Muscle Regulation Of Muscle Cell Differentiation Response To Denervation Involved In Regulation Of Muscle Adaptation Positive Regulation Of Skeletal Muscle Tissue Growth Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Z Disc Porin Activity Voltage-gated Monoatomic Anion Channel Activity U2AF Complex MRNA 3'-splice Site Recognition Positive Regulation Of 3'-UTR-mediated MRNA Stabilization MRNA CDS Binding Regulation Of Skeletal Muscle Fiber Differentiation Striated Muscle Thin Filament Muscle Atrophy Response To Muscle Inactivity Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Ribosome Ceramide Binding Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Cytoplasmic Translation Positive Regulation Of Skeletal Muscle Cell Differentiation Muscle Contraction Regulation Of Skeletal Muscle Fiber Development Actin Filament Binding
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