ACTN3 and IVD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACTN3	IVD
Description		actinin alpha 3	isovaleryl-CoA dehydrogenase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Acyl-CoA Dehydrogenase Activity Protein Binding 3-methylbutanoyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	L-leucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Branched-chain Amino Acid Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Nephrin family interactions Striated Muscle Contraction	Branched-chain amino acid catabolism Isovaleric acidemia
Drugs			Flavin adenine dinucleotide Coenzyme A persulfide
Diseases			Isovaleric acidemia (IVA)
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)	Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) FEV1 ( 30804560) Idiopathic pulmonary fibrosis ( 31710517) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 30804560) Malaria ( 31844061) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)
Interacting Genes		61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426	4 interacting genes: ACTN3 GPSM3 MGAT5B PNMA1
Entrez ID		89	3712
HPRD ID		02148	09516
Ensembl ID		ENSG00000248746	ENSG00000128928
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	A0A0A0MT83 A0A0S2Z4K7 P26440
PDB IDs		1TJT 1WKU 3LUE	1IVH 8SGR
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding	Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Negative Regulation Of Relaxation Of Muscle Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Bone Mineralization Involved In Bone Maturation Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Negative Regulation Of Oxidative Phosphorylation Muscle Atrophy Negative Regulation Of Cellular Respiration Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Adaptation Response To Inactivity Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Relaxation Of Muscle Positive Regulation Of Striated Muscle Tissue Development Negative Regulation Of Glycolytic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Skeletal Muscle Contraction Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Oxidative Phosphorylation Pseudopodium Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of ATP Metabolic Process Regulation Of Aerobic Respiration Focal Adhesion Assembly GTPase Regulator Activity Bone Morphogenesis Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Cell-substrate Junction Assembly Structural Constituent Of Muscle Regulation Of Striated Muscle Tissue Development Cell-substrate Junction Organization Regulation Of Cellular Respiration Positive Regulation Of Bone Mineralization Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation
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