ACTN3 and ASB9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACTN3	ASB9
Description		actinin alpha 3	ankyrin repeat and SOCS box containing 9
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome	Mitochondrion Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process
Pathways		Nephrin family interactions Striated Muscle Contraction	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)	Metabolite levels ( 23823483)
Interacting Genes		61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426	11 interacting genes: ACTN3 ASB13 CKB CKMT1A CKMT1B EXOSC1 HIF1AN LCK PLCG2 RELA UBE2D1
Entrez ID		89	140462
HPRD ID		02148	06452
Ensembl ID		ENSG00000248746	ENSG00000102048
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	A0A024RBW7 Q96DX5
PDB IDs		1TJT 1WKU 3LUE	3D9H 3ZKJ 3ZNG 6V9H
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding	Phosphocreatine Biosynthetic Process Creatine Kinase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ankyrin Repeat Binding Positive Regulation Of T Cell Receptor Signaling Pathway Modified Amino Acid Metabolic Process Positive Regulation Of Antigen Receptor-mediated Signaling Pathway NF-kappaB Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Organophosphate Biosynthetic Process Positive Regulation Of Interleukin-12 Production Kinase Activity Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Release Of Sequestered Calcium Ion Into Cytosol Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of Sequestering Of Calcium Ion [protein]-asparagine 3-dioxygenase Activity Regulation Of Interleukin-12 Production Cytosol Platelet Activation Catalytic Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Futile Creatine Cycle ATP Binding Immune Response-activating Signaling Pathway NF-kappaB P50/p65 Complex Peptidyl-aspartic Acid 3-dioxygenase Activity Calcium Ion Transmembrane Import Into Cytosol Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Bone Mineralization Involved In Bone Maturation Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Peptidyl-histidine Dioxygenase Activity Organophosphate Metabolic Process Immune Response-regulating Signaling Pathway Activation Of Immune Response T Cell Receptor Signaling Pathway
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