ACTN3 and PLEKHG2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ACTN3	PLEKHG2
Gene Name		actinin, alpha 3 (gene/pseudogene)	pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Protein Homodimerization Activity	Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Muscle Filament Sliding Regulation Of Apoptotic Process Focal Adhesion Assembly	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Striated Muscle Contraction Nephrin interactions	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		17 interactors: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2	8 interactors: ACTN3 APP CDC42 GNB1 GNG2 RAC1 RHOA XRN1
Entrez ID		89	64857
HPRD ID		02148	15148
Ensembl ID		ENSG00000248746	ENSG00000090924
Uniprot IDs		B4DZQ2 Q08043 Q4VAM3	E7ESZ3 Q9H7P9
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Regulation Of Cell Death Cellular Component Assembly Protein Localization To Cell Junction Platelet Degranulation Regulation Of Apoptotic Process Actin Filament-based Process Actin Crosslink Formation Blood Coagulation Hemostasis Protein Polyubiquitination Focal Adhesion Assembly Platelet Activation Apoptotic Process Cell Junction Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway NIK/NF-kappaB Signaling Cell-cell Junction Organization Programmed Cell Death Protein Autoubiquitination Cell Death Death Regulation Of Body Fluid Levels Tight Junction Assembly Adherens Junction Assembly Actin Cytoskeleton Organization Wound Healing Cytoskeleton Organization Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Protein Homooligomerization Positive Regulation Of Transporter Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Cardiac Muscle Thin Filament Assembly Actin Filament Bundle Assembly Response To Wounding Regulation Of Signal Transduction Actin Filament Organization Apical Junction Assembly Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Ion Transmembrane Transport Myofibril Assembly Exocytosis Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cytokine Production Adherens Junction Organization Regulation Of Signaling Cellular Response To Tumor Necrosis Factor	Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell-cell Junction Organization Cell Activation Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Axonogenesis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Positive Regulation Of Cell Morphogenesis Involved In Differentiation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Small GTPase Mediated Signal Transduction Cellular Response To Catecholamine Stimulus Neuron Projection Morphogenesis Actin Filament-based Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Cycle Process Movement Of Cell Or Subcellular Component Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Involved In Differentiation Dopamine Receptor Signaling Pathway Substantia Nigra Development Brain Development Cellular Response To Glucagon Stimulus Positive Regulation Of Cytokinesis Head Development Positive Regulation Of Cell Projection Organization Neuron Projection Development Positive Regulation Of Cell Cycle Positive Regulation Of Stress Fiber Assembly Cellular Response To Fatty Acid Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Response To External Stimulus Regulation Of Phosphatidylinositol 3-kinase Activity Response To Glucagon
Tagcloud ?		ace bdkrb2 chi2 cl cmj competition counter discriminate distributions elite explosive forward genotypic italian italians jump leg look players sedentary sj soccer squat stepwise strength top traits variance	abl1 candidates cdc42 constitutively csrc cytoskeletal ephrinb2 flj00018 gbetagamma gtp guanine hek293 heterotrimeric homology kinse mutagenesis partner phosphorylated pik3r3 rac reorganization rho rhogef sh2 substitution throughput turn tyr489 tyrosine
Tagcloud (Difference) ?		ace bdkrb2 chi2 cl cmj competition counter discriminate distributions elite explosive forward genotypic italian italians jump leg look players sedentary sj soccer squat stepwise strength top traits variance	abl1 candidates cdc42 constitutively csrc cytoskeletal ephrinb2 flj00018 gbetagamma gtp guanine hek293 heterotrimeric homology kinse mutagenesis partner phosphorylated pik3r3 rac reorganization rho rhogef sh2 substitution throughput turn tyr489 tyrosine
Tagcloud (Intersection) ?