CBY2 and ISCU

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBY2	ISCU
Description		chibby family member 2	iron-sulfur cluster assembly enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasmic Vesicle	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	Protein Binding Identical Protein Binding	Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding Molecular Adaptor Activity Iron-sulfur Cluster Chaperone Activity
	Biological Process		Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Iron Ion Import Across Plasma Membrane
Pathways			Maturation of replicase proteins
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Intraocular pressure ( 29617998)
Interacting Genes		119 interacting genes: ACTN1 AIMP2 AIRIM ARHGEF40 ARMC7 BEX3 C19orf44 CCDC146 CCDC185 CCDC187 CCDC198 CCDC57 CCHCR1 CCNG1 CDC23 CDC37 CDK18 CDK2 CEP44 CEP55 CEP57L1 CEP95 CHCHD3 CHIC2 CIBAR1 CKS1B CNNM3 CYTH4 DGCR6 DTNB DUSP14 DZIP1L EFCAB3 EIF4E2 ELOA ENKD1 FAM161A FANCG FARS2 FBXO17 FRS3 GADD45A GADD45GIP1 GOLGA2 GOLGA6A GOLGA6L2 GRAP2 HAUS1 HSF2BP ING5 ISCU KIAA0408 KIFC3 KLC3 LATS1 LENG1 LMO1 LMO2 LMO3 LNX1 MCRS1 MED28 METTL17 MLH1 MMAB MOS NDUFA5 NEK6 NINL NME7 NTAQ1 OIP5 PID1 PIN1 PLEKHN1 POLR1C PPFIA3 PPP1R13B PPP1R18 PRPF18 PRPF31 RCOR3 RNF6 RPL9 RTP5 RUNX1T1 SCNM1 SDCBP SH3RF2 SNAPC5 SSX3 SYCE1 SYT17 TCEA2 TCEANC TCHP TEX11 TRIM42 TRIML2 TSC2 TSGA10 TSGA10IP TUBGCP4 TXK TXLNA TXLNB USHBP1 ZC2HC1C ZFYVE26 ZMAT2 ZNF250 ZNF417 ZNF564 ZNF572 ZNF581 ZNF655 ZNF688 ZNF764 ZNF785	17 interacting genes: AGTRAP BANP CBY2 CCDC136 CCDC172 FAM9B GOLGA2 GOLGA6L9 HPRT1 IKZF1 KRT34 KRT40 LNX1 MID2 NECAB2 NUP62 PICK1
Entrez ID		220082	23479
HPRD ID		14856	14828
Ensembl ID		ENSG00000174015	ENSG00000136003
Uniprot IDs		A0A140VJV5 Q8NA61	B1P7G3 B3KQ30 B4DNC9 Q9H1K1
PDB IDs			5KZ5 5WKP 5WLW 6NZU 6UXE 6W1D 6WI2 6WIH 7RTK 8PK8 8PK9 8PKA 8RMC 8RMD 8RME 8RMF 8RMG 8TVT
Enriched GO Terms of Interacting Partners?		Protein Binding Centrosome Cytoskeleton Centriole Spindle Pole Microtubule-based Process Microtubule Organizing Center Organization Organelle Organization Cell Division Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Ciliary Basal Body Male Meiosis Chromosome Segregation Microtubule Cytoskeleton Organization Centrosome Cycle Microtubule Binding	Identical Protein Binding
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