SPERT and MMAB

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPERT	MMAB
Gene Name		spermatid associated	methylmalonic aciduria (cobalamin deficiency) cblB type
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Membrane-bounded Vesicle	Mitochondrial Matrix
	Molecular Function		ATP Binding Cob(I)yrinic Acid A,c-diamide Adenosyltransferase Activity
	Biological Process		Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Cobalamin Metabolic Process Cobalamin Biosynthetic Process Small Molecule Metabolic Process
Pathways			Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs			Hydroxocobalamin
Diseases
GWAS			HDL cholesterol ( 18193043 20864672 19060906 20686565)
Protein-Protein Interactions		63 interactors: ACTN1 ARHGEF40 ARMC7 C14orf105 C19orf44 C1orf109 CCDC146 CCNG1 CDC23 CEP44 CEP57L1 CEP95 CHCHD3 CHIC2 CKS1B CNNM3 CTNNAL1 DGCR6 DUSP14 DZIP1L EIF4E2 ENKD1 FAM161A FRS3 GOLGA6L2 HAUS1 KIFC3 KLC3 LATS1 LENG1 LMO1 LMO2 LMO3 MED28 METTL17 MLH1 MMAB MOS NINL PID1 PIN1 PLEKHN1 PPP1R18 RPL9 RTP5 RUNX1T1 SCNM1 SH3RF2 SYCE1 TCEANC TCEB3 TEX11 TRIM42 TSC2 TSGA10 TUBGCP4 TXLNA TXLNB ZC2HC1C ZMAT2 ZNF564 ZNF581 ZNF655	2 interactors: MTRR SPERT
Entrez ID		220082	326625
HPRD ID		14856	07398
Ensembl ID		ENSG00000174015	ENSG00000139428
Uniprot IDs		Q8NA61	Q96EY8
PDB IDs			2IDX
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Cell Cycle Male Meiosis Chromosome Segregation Organelle Organization Regulation Of Cell Cycle Chromosome Segregation Negative Regulation Of Phosphorylation Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Synapsis Homologous Chromosome Segregation Negative Regulation Of Cell Cycle Resolution Of Meiotic Recombination Intermediates Negative Regulation Of MAPK Cascade Mitotic Cell Cycle Process Regulation Of Phosphorus Metabolic Process Microtubule-based Process Mitotic Cell Cycle Meiotic Chromosome Segregation Meiotic Cell Cycle Regulation Of Phosphorylation Chromosome Separation Regulation Of Protein Phosphorylation Synaptonemal Complex Assembly Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Synaptonemal Complex Organization Meiosis I Regulation Of Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Gene Expression G2/M Transition Of Mitotic Cell Cycle Metaphase Plate Congression Spindle Organization Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Meiotic Metaphase I Plate Congression Negative Regulation Of Mitochondrial DNA Replication Meiotic Spindle Midzone Assembly Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Protein Serine/threonine Kinase Activity Cellular Component Assembly Negative Regulation Of Transferase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Nuclear Division	Folic Acid Metabolic Process Methionine Biosynthetic Process Cobalamin Metabolic Process Methionine Metabolic Process Sulfur Amino Acid Biosynthetic Process Sulfur Amino Acid Metabolic Process Folic Acid-containing Compound Metabolic Process Pteridine-containing Compound Metabolic Process DNA Methylation Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process DNA Modification Dicarboxylic Acid Metabolic Process Vitamin Metabolic Process Cellular Amino Acid Biosynthetic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Regulation Of Gene Expression, Epigenetic Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Alpha-amino Acid Metabolic Process Cofactor Metabolic Process Sulfur Compound Metabolic Process Methylation Cellular Amino Acid Metabolic Process
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